Zhou Jiaojiao, Que Jianyu, Wang Yida, Ren Li, Zhang Saina, Ma Xianglin, Fan Yintai, Zhang Qing'e, Chen Xueyan
National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Xiamen Xianyue Hospital, Xianyue Hospital Affiliated with Xiamen Medical College, Fujian Psychiatric Center, Fujian Clinical Research Center for Mental Disorders, Fujian, China.
Front Psychiatry. 2025 Apr 24;16:1485127. doi: 10.3389/fpsyt.2025.1485127. eCollection 2025.
Limited research has explored the associations between sleep disturbances (SD) and cognitive impairment (CI) in elderly patients with depression, particularly by incorporating polysomnography (PSG) to assess sleep quality. This study was conducted to determine correlations between PSG-quantified sleep parameters and CI among individuals with late-life depression.
65 elderly patients with depression were included in the study. The sleep status was assessed using PSG, while cognitive function was evaluated using the Mini-Mental State Examination (MMSE). The correlation between PSG-measured sleep parameters and cognitive function was analyzed.
CI was observed in 31 (47.7%) individuals. Depressed elderly patients with CI exhibited a shorter total sleep time (TST) compared to those without CI. Furthermore, their sleep efficiency (SE) was reduced as evidenced by shortened durations and proportions of N1 and N3. Conversely, the proportion of non-rapid eye movement (NREM) and N2 increased in this group. Additionally, both the duration and proportion of rapid eye movement (REM) were decreased. Spearman correlation analysis revealed a linear relationship between the MMSE score and various sleep parameters. However, in the multiple linear regression model, only the proportions of NREM exhibited a significant linear relationship with the MMSE scores.
In elderly patients with depression, a significant linear relationship was observed between the MMSE score and various sleep parameters measured by PSG.
有限的研究探讨了老年抑郁症患者睡眠障碍（SD）与认知障碍（CI）之间的关联，特别是通过采用多导睡眠图（PSG）来评估睡眠质量。本研究旨在确定老年抑郁症患者中PSG量化的睡眠参数与CI之间的相关性。
65例老年抑郁症患者纳入本研究。使用PSG评估睡眠状态，同时使用简易精神状态检查表（MMSE）评估认知功能。分析PSG测量的睡眠参数与认知功能之间的相关性。
31例（47.7%）患者存在CI。与无CI的老年抑郁症患者相比，存在CI的患者总睡眠时间（TST）更短。此外，他们的睡眠效率（SE）降低，表现为N1和N3的持续时间和比例缩短。相反，该组中非快速眼动（NREM）和N2的比例增加。此外，快速眼动（REM）的持续时间和比例均降低。Spearman相关性分析显示MMSE评分与各种睡眠参数之间存在线性关系。然而，在多元线性回归模型中，只有NREM比例与MMSE评分存在显著线性关系。
在老年抑郁症患者中，观察到MMSE评分与PSG测量的各种睡眠参数之间存在显著线性关系。
