Health Management Center, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
J Pharm Biomed Anal. 2021 Feb 20;195:113869. doi: 10.1016/j.jpba.2020.113869. Epub 2020 Dec 25.
An H NMR-based metabolomics approach was conducted to holisticly explore the effect of Xue Fu Zhu Yu (XFZY) capsule (a well-known Chinese herbal medicine) on high-fat diets combined with coronary artery ligation induced coronary heart disease (CHD) model rats. 1H NMR-based metabolomics approach combined with multivariate analysis was performed to explore potential biomarkers, a total of 20 metabolites were confirmed as contributors to the discrimination of model group and sham group. We investigated the dynamic metabolic characteristics of XFZY capsule on CHD rats, lactate, glutamine, pyruvate, citrate, choline and taurine were potential biomarkers of early effect. More potential biomarkers changed after 28 days of medication, XFZY capsules primarily influenced the taurine and hypotaurine metabolism, glycine, serine and threonine metabolism, glyoxylate and dicarboxylate metabolism, purine metabolism, glycolysis/gluconeogenesis, amino sugar and nucleotide sugar metabolism, primary bile acid biosynthesis.
采用基于 1H NMR 的代谢组学方法全面探讨了血府逐瘀（XFZY）胶囊（一种著名的中药）对高脂肪饮食联合冠状动脉结扎诱导的冠心病（CHD）模型大鼠的影响。采用基于 1H NMR 的代谢组学方法结合多元分析，以探索潜在的生物标志物，共确定 20 种代谢物可作为区分模型组和假手术组的指标。我们研究了 XFZY 胶囊对 CHD 大鼠的动态代谢特征，乳酸盐、谷氨酰胺、丙酮酸、柠檬酸、胆碱和牛磺酸是早期作用的潜在生物标志物。28 天用药后更多潜在的生物标志物发生变化，XFZY 胶囊主要影响牛磺酸和次牛磺酸代谢、甘氨酸、丝氨酸和苏氨酸代谢、乙醛酸和二羧酸代谢、嘌呤代谢、糖酵解/糖异生、氨基糖和核苷酸糖代谢、初级胆汁酸生物合成。
