Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Saharanpur Campus, Paper Mill Road, Saharanpur, 247001, Uttar Pradesh, India.
School of Chemical Engineering, Yeungnam University, Gyeongsan, 38541, South Korea.
Carbohydr Res. 2021 Jan;499:108222. doi: 10.1016/j.carres.2020.108222. Epub 2020 Dec 16.
In this study, novel redox-sensitive nanoparticles based on xylan-lipoic acid (Xyl-LA) conjugate were developed for tumor targeted delivery of niclosamide (Nic) in cancer therapy. The niclosamide loaded xylan-lipoic acid conjugate nanoparticles (Xyl-LA/Nic NPs) showed redox responsive behaviour in presence of reductive glutathione (GSH), which indicate their suitability for intracellular drug release. The obtained Xyl-LA/Nic NPs exhibited uniform particle size (196 ± 1.64 nm), high loading capacity (~28.6 wt %) and excellent blood compatibility. The anticancer activity of the Niclosamide and the Xyl-LA/Nic NPs against the colon carcinoma cell lines (HCT-15, Colo-320) were evaluated by MTT assay and the overall results indicate that the Xyl-LA/Nic NPs significantly enhanced the therapeutic efficiency of niclosamide in cancer therapy.
在这项研究中，开发了基于木聚糖-硫辛酸（Xyl-LA）缀合物的新型氧化还原敏感纳米粒子，用于癌症治疗中尼氯柳胺（Nic）的肿瘤靶向递送。载有尼氯柳胺的木聚糖-硫辛酸缀合物纳米粒子（Xyl-LA/Nic NPs）在还原性谷胱甘肽（GSH）存在下表现出氧化还原响应行为，表明它们适合细胞内药物释放。所得到的 Xyl-LA/Nic NPs 表现出均匀的粒径（196 ± 1.64nm）、高载药量（~28.6wt%）和优异的血液相容性。通过 MTT 测定评估了尼氯柳胺和 Xyl-LA/Nic NPs 对结肠癌细胞系（HCT-15、Colo-320）的抗癌活性，结果表明 Xyl-LA/Nic NPs 显著提高了尼氯柳胺在癌症治疗中的治疗效率。
