da Cruz Filho Iranildo José, de Souza Thammyris Pires, Dos Anjos Santos Carolina Ávila, de Morais Araújo Maria Augusta, de Oliveira Moraes Miranda Josué Filipe, de Oliveira Queirós Maria Emanuelle, Filho Denilson José Nogueira Correia, da Conceição Alves de Lima Alice, Marques Diego Santa Clara, do Carmo Alves de Lima Maria
Department of Antibiotics, Biosciences Center, Federal University of Pernambuco, 50.670-420, Recife,, Pernambuco Brazil.
3 Biotech. 2023 Mar;13(3):93. doi: 10.1007/s13205-023-03506-1. Epub 2023 Feb 21.
This work aimed to isolate and characterize xylans from branches and leaves of , in addition to evaluating its in vitro biological and prebiotic potential. The results showed that the chemical structure of the obtained polysaccharides is similar being classified as homoxylans. The xylans presented an amorphous structure, in addition to being thermally stable and presenting a molecular weight close to 36 g/mol. With regard to biological activities, it was observed that xylans were able to promote low antioxidant activity (< 50%) in the different assays evaluated. The xylans also showed no toxicity against normal cells, in addition to being able to stimulate cells of the immune system and showing promise as anticoagulant agents. In addition to presenting promising antitumor activity in vitro In assays of emulsifying activity, xylans were able to emulsify lipids in percentages below 50%. Regarding in vitro prebiotic activity, xylans were able to stimulate and promote the growth of different probiotics. Therefore, this study, in addition to being a pioneer, contributes to the application of these polysaccharides in the biomedical and food areas.
The online version contains supplementary material available at 10.1007/s13205-023-03506-1.
本研究旨在从[植物名称]的枝叶中分离并表征木聚糖，此外还评估其体外生物学和益生元潜力。结果表明，所获得的多糖化学结构相似，归类为同型木聚糖。木聚糖呈现无定形结构，此外还具有热稳定性，分子量接近36 g/mol。关于生物活性，观察到木聚糖在不同评估试验中能够促进低抗氧化活性（<50%）。木聚糖对正常细胞也无毒性，此外还能够刺激免疫系统细胞，并有望作为抗凝血剂。除了在体外呈现出有前景的抗肿瘤活性外，在乳化活性试验中，木聚糖能够以低于50%的百分比乳化脂质。关于体外益生元活性，木聚糖能够刺激并促进不同益生菌的生长。因此，本研究不仅具有开创性，还为这些多糖在生物医学和食品领域的应用做出了贡献。
在线版本包含可在10.1007/s13205-023-03506-1获取的补充材料。
