Department of Biostatistics and Epidemiology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Department of Family Medicine and Osteopathic Manipulative Medicine, NorTex, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Nutrients. 2021 Jan 2;13(1):142. doi: 10.3390/nu13010142.
Liver fibrosis represents the consequences of chronic liver injury. Individuals with alcoholic or nonalcoholic liver diseases are at high risk of magnesium deficiency. This study aimed to evaluate the association between magnesium and calcium intakes and significant liver fibrosis, and whether the associations differ by alcohol drinking status. Based on the National Health and Nutrition Examination Survey (NHANES) 2017-2018, the study included 4166 participants aged >18 years who completed the transient elastography examination and had data available on magnesium intake. The median liver stiffness of 8.2 kPa was used to identify subjects with significant fibrosis (≥F2). The age-adjusted prevalence of significant fibrosis was 12.81%. Overall total magnesium intake was marginally associated with reduced odds of significant fibrosis ( trend = 0.14). The inverse association of total magnesium intake with significant fibrosis was primarily presented among those who had daily calcium intake <1200 mg. There were no clear associations for significant fibrosis with calcium intake. Findings suggest that high total magnesium alone may reduce risk of significant fibrosis. Further studies are needed to confirm these findings.
肝纤维化代表慢性肝损伤的后果。患有酒精性或非酒精性肝病的个体镁缺乏的风险很高。本研究旨在评估镁和钙摄入量与显著肝纤维化之间的关联，以及这些关联是否因饮酒状况而异。基于 2017-2018 年全国健康和营养调查（NHANES），本研究纳入了 4166 名年龄>18 岁的参与者，他们完成了瞬时弹性成像检查，并且有镁摄入量的数据。中位数为 8.2kPa 的肝硬度用于识别有显著纤维化（≥F2）的受试者。调整年龄后的显著纤维化患病率为 12.81%。总体镁总摄入量与显著纤维化的几率降低呈边缘相关（趋势=0.14）。镁总摄入量与显著纤维化之间的反比关系主要见于每日钙摄入量<1200mg 的人群中。钙摄入量与显著纤维化之间没有明显的关联。研究结果表明，高总镁可能单独降低显著纤维化的风险。需要进一步的研究来证实这些发现。
