Department of Anesthesia Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS B3H4H7, Canada.
Department of Pharmacology, Dalhousie University, Halifax, NS B3H4H7, Canada.
Molecules. 2021 Jan 2;26(1):189. doi: 10.3390/molecules26010189.
Iron is an essential element in multiple biochemical pathways in humans and pathogens. As part of the innate immune response in local infection, iron availability is restricted locally in order to reduce overproduction of reactive oxygen species by the host and to attenuate bacterial growth. This physiological regulation represents the rationale for the therapeutic use of iron chelators to support induced iron deprivation and to treat infections. In this review paper we discuss the importance of iron regulation through examples of local infection and the potential of iron chelation in treating infection.
铁是人体和病原体中多种生化途径所必需的元素。作为局部感染固有免疫反应的一部分，铁的供应在局部受到限制，以减少宿主产生的活性氧过量，并减弱细菌生长。这种生理调节为铁螯合剂的治疗用途提供了理论依据，即支持诱导性缺铁和治疗感染。在这篇综述文章中，我们通过局部感染的例子讨论了铁调节的重要性，并探讨了铁螯合在治疗感染方面的潜力。
