Department of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, P. R. China.
The First Clinical Medical College, Jinan University, Guangzhou, P. R. China.
Biomarkers. 2021 Mar;26(2):95-102. doi: 10.1080/1354750X.2020.1871411. Epub 2021 Jan 17.
To assess the diagnostic value of Trefoil factor 3 (TFF3) and the correlation between TFF3 expression and clinicopathological features in patients with gastric cancer (GC).
PubMed, The Cochrane, EMbase, and Web of Science were retrieved comprehensively to collect relevant literature. The search ended on 31 May 2020. All data were analyzed using PubMed, The Cochrane, EMbase, and Web of Science were retrieved to collect relevant articles. All data from the included studies were subjected to meta-analysis using Stata 12.0 software.
Seventeen studies involved 4654 subjects were included. For the diagnostic value of TFF3 for GC, the sensitivity, specificity, and AUC were 0.71, 0.80, and 0.80, respectively. For the clinicopathological value of TFF3, tissue TFF3 expression showed a higher risk of lymph node metastasis (OR 2.20, 95% CI 1.75-2.78, < 0.001) and muscularis propria invasion (≥T2) (1.51, 1.13-2.03, = 0.006), as well as worse TNM stage (2.26, 1.63-3.12, < 0.001) and histological type (1.72, 1.34-2.20, < 0.001), while no apparent relationship was found for serous membrane invasion (T4), venous invasion, and peritoneal metastasis.
TFF3 may be a promising biomarker for GC, and the TFF3 expression is likely to be involved in the invasion, metastasis, and differentiation of GC.
评估三叶因子 3（TFF3）在胃癌（GC）患者中的诊断价值及其与临床病理特征的相关性。
全面检索 PubMed、The Cochrane、EMbase 和 Web of Science，收集相关文献。检索截止日期为 2020 年 5 月 31 日。使用 Stata 12.0 软件对纳入研究中的所有数据进行荟萃分析。
共纳入 17 项研究，涉及 4654 例患者。对于 TFF3 对 GC 的诊断价值，灵敏度、特异度和 AUC 分别为 0.71、0.80 和 0.80。对于 TFF3 的临床病理价值，组织 TFF3 表达与淋巴结转移（OR 2.20，95%CI 1.75-2.78， < 0.001）和固有肌层侵犯（≥T2）（1.51，1.13-2.03， = 0.006）的风险更高，以及更差的 TNM 分期（2.26，1.63-3.12， < 0.001）和组织学类型（1.72，1.34-2.20， < 0.001），而浆膜侵犯（T4）、静脉侵犯和腹膜转移与 TFF3 表达无明显相关性。
TFF3 可能是 GC 有前途的生物标志物，TFF3 表达可能参与 GC 的侵袭、转移和分化。
