University of Houston College of Pharmacy, Department of Pharmaceutical Health Outcomes and Policy, United States.
Duquesne University School of Pharmacy Graduate School of Pharmaceutical Sciences, 418A Mellon Hall, United States.
Patient Educ Couns. 2021 Jul;104(7):1756-1764. doi: 10.1016/j.pec.2020.12.009. Epub 2021 Jan 2.
This study explored if a motivational interviewing intervention customized for statins impacted adherence to concomitantly used antidiabetic/antihypertensive medications.
The intervention was conducted among patients with a history of suboptimal adherence to statins and included 152 patients in intervention and 304 controls. This retrospective study design identified patients with claims for statins and either antidiabetic/antihypertensive medications. The outcome variable was adherence, measured as proportion of days covered ≥ 0.80, to antidiabetic/antihypertensive medications. Multivariable linear and logistic regression evaluated the effect of intervention on adherence to antidiabetic/antihypertensive medications during the 6 months post-intervention.
The antidiabetic group had 53 intervention patients and 102 controls. The antihypertensive group had 80 intervention patients and 159 controls. There was no significant improvement in adherence for antidiabetic/antihypertensive medications following the intervention. Adherence at baseline was a significant predictor of adherence post-intervention in the antidiabetic (OR = 6.5;P < 0.0001) and antihypertensive (OR = 4.1; P = 0.0001 & β = 0.09; P = 0.008) users. Physician specialty (OR = 3.902; P = 0.01& β = 0.09; P = 0.015) among antidiabetic users and age >70 years (OR = 2.148; P = 0.025) among antihypertensive users were predictors of adherence.
The intervention targeting statin did not significantly improve antihypertensive/antidiabetic adherence.
Targeted interventions tailored to patient past adherence and specific medications should be explored.
本研究探讨了针对他汀类药物的动机性访谈干预是否会影响同时使用的降糖/降压药物的依从性。
该干预措施针对他汀类药物依从性差的患者进行，包括 152 名干预组患者和 304 名对照组患者。这项回顾性研究设计确定了有他汀类药物和/或降糖/降压药物用药史的患者。结局变量为降糖/降压药物的依从性，以覆盖比例≥0.80 的天数来衡量。多变量线性和逻辑回归评估了干预对干预后 6 个月内降糖/降压药物依从性的影响。
降糖组有 53 名干预患者和 102 名对照患者，降压组有 80 名干预患者和 159 名对照患者。干预后，降糖/降压药物的依从性没有显著改善。在降糖（OR=6.5；P<0.0001）和降压（OR=4.1；P=0.0001，β=0.09；P=0.008）使用者中，干预前的依从性是干预后依从性的显著预测因素。降糖患者的医生专业（OR=3.902；P=0.01，β=0.09；P=0.015）和降压患者的年龄>70 岁（OR=2.148；P=0.025）是依从性的预测因素。
针对他汀类药物的干预并未显著改善降压/降糖药物的依从性。
应探索针对患者既往依从性和特定药物的靶向干预措施。
