DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet Glostrup, Glostrup, Denmark
Department of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark.
RMD Open. 2021 Jan;7(1). doi: 10.1136/rmdopen-2020-001505.
In Danish patients with inflammatory rheumatic diseases to explore self-protection strategies and health behaviour including adherence to disease-modifying antirheumatic treatment (DMARD) during the initial phase of the COVID-19 pandemic and again after the reopening of the society started. Furthermore, to identify characteristics of patients with high levels of anxiety and self-isolation.
Patients in routine care followed prospectively in the nationwide DANBIO registry were invited to answer an online questionnaire regarding disease activity and COVID-19 infection, behaviour in March and June 2020. Responses were linked to patient data in DANBIO. Characteristics potentially associated with anxiety, self-isolation and medication adherence (gender/age/diagnosis/education/work status/comorbidity/DMARD/smoking/EQ-5D/disease activity) were explored with multivariable logistic regression analyses.
We included 12 789 patients (8168 rheumatoid arthritis/2068 psoriatic arthritis/1758 axial spondyloarthritis/795 other) of whom 65% were women and 36% treated with biological DMARD. Self-reported COVID-19 prevalence was 0.3%. Patients reported that they were worried to get COVID-19 infection (March/June: 70%/45%) and self-isolated more than others of the same age (48%/38%). The fraction of patients who changed medication due to fear of COVID-19 were 4.1%/0.6%. Female gender, comorbidities, not working, lower education, biological treatment and poor European Quality of life, 5 dimensions were associated with both anxiety and self-isolation.
In >12 000 patients with inflammatory arthritis, we found widespread anxiety and self-isolation, but high medication adherence, in the initial phase of the COVID-19 pandemic. This persisted during the gradual opening of society during the following months. Attention to patients' anxiety and self-isolation is important during this and potential future epidemics.
在丹麦患有炎症性风湿性疾病的患者中，探讨自我保护策略和健康行为，包括在 COVID-19 大流行的初始阶段和社会重新开放后继续接受疾病修饰抗风湿治疗（DMARD）。此外，确定具有高水平焦虑和自我隔离特征的患者。
前瞻性地在全国性的 DANBIO 登记处接受常规治疗的患者被邀请回答一个关于疾病活动和 COVID-19 感染、2020 年 3 月和 6 月行为的在线问卷。回应与 DANBIO 中的患者数据相关联。使用多变量逻辑回归分析探讨可能与焦虑、自我隔离和药物依从性相关的特征（性别/年龄/诊断/教育/工作状态/合并症/ DMARD/吸烟/EQ-5D/疾病活动）。
我们纳入了 12789 名患者（8168 例类风湿关节炎/2068 例银屑病关节炎/1758 例中轴型脊柱关节炎/795 例其他），其中 65%为女性，36%接受生物 DMARD 治疗。自我报告的 COVID-19 患病率为 0.3%。患者报告称他们担心感染 COVID-19（3 月/6 月：70%/45%），并比同年龄的其他人更多地自我隔离（48%/38%）。由于担心 COVID-19 而改变药物治疗的患者比例为 4.1%/0.6%。女性、合并症、不工作、较低的教育程度、生物治疗和较差的欧洲生活质量 5 个维度与焦虑和自我隔离均相关。
在超过 12000 名患有炎症性关节炎的患者中，我们在 COVID-19 大流行的初始阶段发现了广泛的焦虑和自我隔离，但药物依从性较高。这在随后几个月社会逐渐开放期间持续存在。在这一时期和未来可能的疫情中，关注患者的焦虑和自我隔离非常重要。
