COVID-19 大流行期间的长期行为变化以及疫苗接种对炎症性风湿病患者的影响。
Long-term Behavioral Changes During the COVID-19 Pandemic and Impact of Vaccination in Patients With Inflammatory Rheumatic Diseases.
机构信息
B. Glintborg, MD, PhD, DMSc, M. Østergaard, MD, PhD, DMSc, Professor, M.L. Hetland, MD, PhD, DMSc, Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, University Hospital of Copenhagen Rigshospitalet, Glostrup, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen;
D.V. Jensen, MD, DANBIO, Rigshospitalet, Glostrup, Copenhagen, and Department of Rheumatology, Center for Rheumatology and Spine Diseases Gentofte and Herlev Hospital, Gentofte.
出版信息
J Rheumatol. 2022 Oct;49(10):1163-1172. doi: 10.3899/jrheum.211280. Epub 2022 Jun 15.
OBJECTIVE
To explore anxiety and self-isolation in patients with inflammatory rheumatic disease (IRD)15 months into the coronavirus disease 2019 (COVID-19) pandemic, including attitudes toward and effects of SARS-CoV-2 vaccination.
METHODS
A nationwide online survey was conducted at 3 timepoints: May 2020, November 2020, and May 2021. Patients with IRD followed in the Danish Rheumatology Quality Registry (DANBIO) were asked about the effects of the pandemic, including SARS-CoV-2 infection and their behavior, anxiety, and concerns. The May 2021 survey included attitudes toward SARS-CoV-2 and influenza vaccination. Characteristics associated with self-isolation in May 2021 were explored with adjusted logistic regression analyses that included patient characteristics and SARS-CoV-2 vaccination status.
RESULTS
Respondents to surveys 1, 2, and 3 included 12,789; 14,755; and 13,921 patients, respectively; 64% had rheumatoid arthritis and 63% were female. Anxiety and concerns were highest in May 2020 and decreased to stable levels in November 2020 and May 2021; 86%, 50%, and 52% of respondents reported self-isolation, respectively. In May 2021, 4% of respondents self-reported previous SARS-CoV-2 infection. The SARS-CoV-2 vaccine acceptance rate was 86%, and the proportion of patients vaccinated against influenza had increased from 50% in winter 2019-2020 to 64% in winter 2020-2021. The proportion of patients with anxiety appeared similar among those vaccinated and unvaccinated against SARS-CoV-2. In multivariable analyses, being unvaccinated, female gender, receiving biologic drugs, and poor quality of life were independently associated with self-isolation.
CONCLUSION
Levels of anxiety and self-isolation decreased after the initial lockdown period in patients with IRD. Half of the patients reported self-isolation in May 2021, a phase that included widespread reopening of society and large-scale vaccination. The lack of prepandemic data prevented a full understanding of the long-term effects of the pandemic on anxiety and self-isolation in patients with IRD.
目的
探讨在 COVID-19 大流行的 15 个月中，炎症性风湿病（IRD）患者的焦虑和自我隔离情况，包括对 SARS-CoV-2 疫苗的态度和影响。
方法
在三个时间点进行了一项全国性的在线调查：2020 年 5 月、2020 年 11 月和 2021 年 5 月。在丹麦风湿病质量登记处（DANBIO）接受治疗的 IRD 患者被问及大流行的影响，包括 SARS-CoV-2 感染及其行为、焦虑和担忧。2021 年 5 月的调查还包括对 SARS-CoV-2 和流感疫苗接种的态度。使用调整后的逻辑回归分析探讨了 2021 年 5 月自我隔离的特征，其中包括患者特征和 SARS-CoV-2 疫苗接种状况。
结果
第 1、2 和 3 次调查的应答者分别为 12789、14755 和 13921 人；64%患有类风湿关节炎，63%为女性。2020 年 5 月焦虑和担忧最高，2020 年 11 月和 2021 年 5 月降至稳定水平；分别有 86%、50%和 52%的受访者报告自我隔离。2021 年 5 月，4%的受访者自我报告以前感染过 SARS-CoV-2。SARS-CoV-2 疫苗接种率为 86%，2019-2020 年冬季接种流感疫苗的患者比例从 50%增加到 2020-2021 年冬季的 64%。在接受 SARS-CoV-2 疫苗和未接种疫苗的患者中，焦虑患者的比例似乎相似。在多变量分析中，未接种疫苗、女性、接受生物制剂药物和生活质量差与自我隔离独立相关。
结论
IRD 患者在最初的封锁期后，焦虑和自我隔离水平下降。在 2021 年 5 月，有一半的患者报告自我隔离，这一阶段包括社会的大规模重新开放和大规模疫苗接种。缺乏大流行前的数据，使得我们无法充分了解大流行对 IRD 患者焦虑和自我隔离的长期影响。
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