硬纤维瘤（胶原纤维瘤）的临床病理、影像学和遗传学特征的最新研究进展。
An Update on Clinicopathological, Imaging and Genetic Features of Desmoplastic Fibroblastoma (Collagenous Fibroma).
机构信息
Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan;
出版信息
In Vivo. 2021 Jan-Feb;35(1):69-73. doi: 10.21873/invivo.12233.
Desmoplastic fibroblastoma (also known as collagenous fibroma) is an uncommon benign fibroblastic/myofibroblastic neoplasm that primarily arises in the subcutaneous tissue of upper extremity. Magnetic resonance imaging reveals a well-defined mass in intimate association with dense connective tissue and prominent low signal intensity on all pulse sequences. Peripheral and septal enhancement is usually seen after intravenous contrast. Histologically, the lesion is paucicellular and consists of spindle to stellate-shaped cells embedded in a collagenous or myxocollagenous stroma with low vascularity. Diffuse and strong nuclear immunoreactivity for FOS-like antigen 1 seems to be characteristic of desmoplastic fibroblastoma. Cytogenetic studies have demonstrated the presence of 11q12 rearrangements and an identical t(2;11)(q31;q12) translocation. This review provides an updated overview of the clinical, radiological, histological, cytogenetic and molecular genetic features of desmoplastic fibroblastoma and discusses the relationship to fibroma of tendon sheath.
促卵泡素相关蛋白 1 阳性弥漫强表达可能是促纤维组织细胞瘤的特征。细胞遗传学研究表明存在 11q12 重排和相同的 t(2;11)(q31;q12)易位。本文就促纤维组织细胞瘤的临床、放射学、组织学、细胞遗传学和分子遗传学特征进行综述，并探讨其与腱鞘纤维瘤的关系。
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