（2；11）（q31；q12）易位在胶原性纤维瘤（促结缔组织增生性纤维母细胞瘤）中反复出现。
Translocation (2;11)(q31;q12) is recurrent in collagenous fibroma (desmoplastic fibroblastoma).
作者信息
Bernal Kerry, Nelson Marilu, Neff James R, Nielsen Stephen M, Bridge Julia A
机构信息
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.
出版信息
Cancer Genet Cytogenet. 2004 Mar;149(2):161-3. doi: 10.1016/S0165-4608(03)00298-X.
Collagenous fibroma (desmoplastic fibroblastoma) is a rare, benign tumor composed of spindle and stellate-shaped fibroblasts and myofibroblasts in a densely collagenous background. A t(2;11)(q31;q12) has been reported in one case of collagenous fibroma and a rearrangement of the 11q12 breakpoint in a second case. In the present study, we detected a t(2;11) identical to that previously described in a collagenous fibroma arising in the supraclavicular fossa of a 55-year-old man. This finding confirms the nonrandom association of t(2;11)(q31;q12) with collagenous fibroma.
胶原纤维瘤（促结缔组织增生性纤维母细胞瘤）是一种罕见的良性肿瘤，由梭形和星状成纤维细胞及肌成纤维细胞构成，背景为致密的胶原组织。曾有1例胶原纤维瘤报告存在t(2;11)(q31;q12)，另1例存在11q12断点重排。在本研究中，我们在一名55岁男性锁骨上窝出现的胶原纤维瘤中检测到与先前描述相同的t(2;11)。这一发现证实了t(2;11)(q31;q12)与胶原纤维瘤之间存在非随机关联。
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