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Toll-like receptor 3 (TLR-3), TLR-4 and CD80 expression in peripheral blood mononuclear cells and urinary CD80 levels in children with idiopathic nephrotic syndrome.特发性肾病综合征患儿外周血单个核细胞中Toll样受体3（TLR-3）、TLR-4及CD80的表达以及尿CD80水平
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Nephrol Dial Transplant. 2012 Jan;27(1):81-9. doi: 10.1093/ndt/gfr271. Epub 2011 May 26.
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Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. toll 样受体及其在感染和免疫中与其他先天受体的相互作用。
Immunity. 2011 May 27;34(5):637-50. doi: 10.1016/j.immuni.2011.05.006.
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多聚肌苷酸诱导维甲酸诱导基因-I 和黑色素瘤分化相关基因 5，并调节足细胞中的炎症。

PolyIC Induces Retinoic Acid-inducible Gene-I and Melanoma Differentiation-associated Gene 5 and Modulates Inflammation in Podocytes.

机构信息

Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan;

出版信息

In Vivo. 2021 Jan-Feb;35(1):147-153. doi: 10.21873/invivo.12242.

DOI:10.21873/invivo.12242
PMID:33402460
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7880774/
Abstract

BACKGROUND/AIM: Viral infection often exacerbates proteinuria, which has been suggested to be due to antiviral responses of podocytes. We examined the effect of polyinosinic-polycytidylic acid (polyIC) on the expression of retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) in differentiated human podocytes in culture.

MATERIALS AND METHODS

The podocytes were treated with 2 ng/ml to 500 μg/ml of polyIC for 3 to 36 h, and also transfected with siRNA against RIG-I and MDA5. F-actin staining was performed to assess actin reorganization.

RESULTS

PolyIC induced the expression of RIG-I and MDA5 in dose- and time-dependent manner, accompanied with interferon-β (IFN-β) and interleukin-6 (IL-6) up-regulation and actin reorganization. Temporal knockdown of RIG-I by siRNA decreased IFN-β expression, while MDA5 siRNA inhibited IFN-β and IL-6 expression. Actin reorganization was attenuated by RIG-I and MDA5 knockdown.

CONCLUSION

RIG-I and MDA5 may play a role in the antiviral responses of podocytes.

摘要

背景/目的：病毒感染常使蛋白尿加重，这被认为是由于足细胞的抗病毒反应。我们研究了多聚肌苷酸-多聚胞苷酸（polyIC）对培养分化的人足细胞中视黄酸诱导基因-I（RIG-I）和黑色素瘤分化相关基因 5（MDA5）表达的影响。

材料和方法

将足细胞用 2ng/ml 至 500μg/ml 的 polyIC 处理 3 至 36 小时，并用 RIG-I 和 MDA5 的 siRNA 转染。通过 F-肌动蛋白染色评估肌动蛋白重排。

结果

polyIC 以剂量和时间依赖的方式诱导 RIG-I 和 MDA5 的表达，伴随干扰素-β（IFN-β）和白细胞介素-6（IL-6）的上调和肌动蛋白重排。通过 siRNA 瞬时敲低 RIG-I 可降低 IFN-β 的表达，而 MDA5 siRNA 抑制 IFN-β 和 IL-6 的表达。RIG-I 和 MDA5 的敲低可减轻肌动蛋白重排。

结论

RIG-I 和 MDA5 可能在足细胞的抗病毒反应中发挥作用。