Syndecan-1 在慢性肝病中的表达：与肝纤维化的相关性。
Expression of Syndecan-1 in Chronic Liver Diseases: Correlation With Hepatic Fibrosis.
机构信息
Department of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece;
Department of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.
出版信息
In Vivo. 2021 Jan-Feb;35(1):333-339. doi: 10.21873/invivo.12264.
BACKGROUND/AIM: The mechanisms underlying the contribution of the heparan sulfate proteoglycan syndecan-1 to liver tissue injury and to crucial biological processes, such as fibrogenesis, remain to be elucidated. Therefore, we investigated the immunohistochemical expression of syndecan-1 in chronic liver diseases (CLDs) and its probable role in hepatic fibrosis.
MATERIALS AND METHODS
Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue sections of biopsy material obtained from 128 patients diagnosed with CLDs. The correlation between syndecan-1 expression and the stage of fibrosis was investigated.
RESULTS
According to the severity of fibrosis, cases were categorized into three groups: early fibrosis; intermediate fibrosis; advanced fibrosis. Syndecan-1 expression was significantly enhanced in advanced fibrosis compared to early (p<0.012) and intermediate (p<0.003) fibrosis.
CONCLUSION
In CLDs, syndecan-1 immunohisto-chemical overexpression was found to be positively correlated with the severity of fibrosis, suggesting its probable role in hepatic fibrogenesis.
背景/目的：硫酸乙酰肝素蛋白聚糖黏附素-1 促进肝组织损伤以及促成纤维化等重要生物学过程的机制仍有待阐明。因此，我们研究了黏附素-1 在慢性肝病（CLD）中的免疫组织化学表达及其在肝纤维化中的可能作用。
材料和方法
对 128 例 CLD 患者的活检组织进行福尔马林固定、石蜡包埋的组织切片进行免疫组织化学染色。研究了黏附素-1 表达与纤维化分期之间的相关性。
结果
根据纤维化的严重程度，病例被分为三组：早期纤维化；中期纤维化；晚期纤维化。与早期（p<0.012）和中期（p<0.003）纤维化相比，晚期纤维化中黏附素-1 的表达显著增强。
结论
在 CLD 中，黏附素-1 的免疫组织化学过度表达与纤维化的严重程度呈正相关，提示其可能在肝纤维化形成中发挥作用。
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