Ross N, English J, Bennett W M
Department of Medicine, Oregon Health Sciences University, Portland.
Nephron. 1988;48(1):58-60. doi: 10.1159/000184870.
Experimental ciclosporin (CSA) nephrotoxicity is reported to be more severe in male versus female rodents. To investigate these sex differences further, groups of male and female Sprague-Dawley rats were pair fed and given either CSA 50 mg/kg or olive oil vehicle by gavage daily for 5 days. Both groups of treated animals showed azotemia and depression of CIn but there were no sex differences. CSA levels were 5,820 ng/ml in females and 6,480 ng/ml in males (p = NS). Although CSA did not produce enzymuria in either sex, females showed more extensive proximal tubular cell vacuolization.
Female Sprague-Dawley rats are equally as susceptible to CSA nephrotoxicity as males. Strain differences or experimental design may account for apparently conflicting results in the literature.
据报道，实验性环孢素（CSA）肾毒性在雄性啮齿动物中比雌性更严重。为了进一步研究这些性别差异，将雄性和雌性Sprague-Dawley大鼠分组进行配对喂养，每天通过灌胃给予50mg/kg CSA或橄榄油载体，持续5天。两组处理过的动物均出现氮质血症和CIn降低，但无性别差异。雌性CSA水平为5820ng/ml，雄性为6480ng/ml（p=无显著性差异）。虽然CSA在两性中均未产生酶尿，但雌性显示出更广泛的近端肾小管细胞空泡化。
雌性Sprague-Dawley大鼠对CSA肾毒性的易感性与雄性相同。品系差异或实验设计可能是文献中结果明显矛盾的原因。
