不同帕金森病认知表型中的疼痛严重程度及干扰情况
Pain Severity and Interference in Different Parkinson's Disease Cognitive Phenotypes.
作者信息
Cruz-Almeida Yenisel, Crowley Samuel J, Tanner Jared, Price Catherine C
机构信息
Pain Research & Intervention Center of Excellence, University of Florida, Gainesville, FL, USA.
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
出版信息
J Pain Res. 2020 Dec 29;13:3493-3497. doi: 10.2147/JPR.S270669. eCollection 2020.
INTRODUCTION
Chronic pain is prevalent in idiopathic Parkinson's disease (PD) with many individuals also experiencing cognitive deficits negatively impacting everyday life.
METHODS
In this study, we examine differences in pain severity and interference between 113 nondemented individuals with idiopathic PD who were statistically classified as having low executive function (n=24), low memory function (n=35), no cognitive deficits (n=54). The individuals with PD were also compared to matched non-PD controls (n=64).
RESULTS
PD participants with low executive function reported significantly higher pain interference (p<0.05), despite reporting similar pain severity levels compared to other phenotypes. These differences remained statistically significant, even after accounting for important confounders such as anxiety and depression (p<0.05).
DISCUSSION
Pain interference in those with lower executive function may represent a target for psychosocial interventions for individuals with pain and PD.
引言
慢性疼痛在特发性帕金森病（PD）中很常见，许多患者还存在认知缺陷，对日常生活产生负面影响。
方法
在本研究中，我们检查了113名非痴呆特发性PD患者的疼痛严重程度和干扰差异，这些患者在统计学上被分类为执行功能低下（n = 24）、记忆功能低下（n = 35）、无认知缺陷（n = 54）。PD患者还与匹配的非PD对照组（n = 64）进行了比较。
结果
尽管与其他表型相比，执行功能低下的PD参与者报告的疼痛严重程度相似，但他们报告的疼痛干扰明显更高（p < 0.05）。即使在考虑了焦虑和抑郁等重要混杂因素后，这些差异仍具有统计学意义（p < 0.05）。
讨论
执行功能较低者的疼痛干扰可能是疼痛和PD患者心理社会干预的一个目标。
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