Ehgoetz Martens Kaylena A, Silveira Carolina R A, Intzandt Brittany N, Almeida Quincy J
Movement Disorders Research and Rehabilitation Centre.
Neuropsychology. 2018 Nov;32(8):950-957. doi: 10.1037/neu0000478. Epub 2018 Oct 4.
Anxiety is common in Parkinson's disease (PD) and frequently a comorbidity that appears alongside nonmotor symptoms such as cognitive deficits; however, the relationship between anxiety and cognition in PD remains poorly understood. The aim of this study was to investigate the relationship between anxiety and specific cognitive domains (e.g., attention/working memory, executive functions, memory, language, and visuospatial function).
A total of 48 individuals with PD and 18 healthy controls were assessed using the State Trait Anxiety Inventory along with a comprehensive neuropsychological battery. Hierarchical multiple regression analysis was used to examine whether trait and/or state anxiety predicted deficits in overall cognitive function (Montreal Cognitive Assessment) and/or specific individual cognitive domains in the PD and healthy control samples while controlling for covariates such as age, depression (Geriatric Depression Scale), and Unified Parkinson's disease Rating Scale motor-subsection-III (PD only).
Results showed that state anxiety in PD significantly predicted performance across an array of cognitive domains, such as attention/working memory, executive functioning, memory, and language, whereas trait anxiety was a predictor only for executive functioning. In contrast, there was no significant relationship between state anxiety and visuospatial ability Conclusions: Overall, these findings highlight that performance in particular cognitive domains are associated with anxiety in PD. Thus, it may be critically important to consider and quantify the contribution of anxiety to cognitive performance when diagnosing and treating dementia and/or mild cognitive impairments in PD. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
焦虑在帕金森病（PD）中很常见，并且常常是一种与认知缺陷等非运动症状同时出现的共病；然而，PD中焦虑与认知之间的关系仍知之甚少。本研究的目的是调查焦虑与特定认知领域（如注意力/工作记忆、执行功能、记忆、语言和视觉空间功能）之间的关系。
使用状态特质焦虑量表以及一套全面的神经心理学测试对48名PD患者和18名健康对照者进行评估。在控制年龄、抑郁（老年抑郁量表）和帕金森病统一评定量表运动部分III（仅针对PD患者）等协变量的情况下，采用分层多元回归分析来检验特质焦虑和/或状态焦虑是否能预测PD患者和健康对照样本在整体认知功能（蒙特利尔认知评估）和/或特定个体认知领域的缺陷。
结果表明，PD患者的状态焦虑显著预测了一系列认知领域的表现，如注意力/工作记忆、执行功能、记忆和语言，而特质焦虑仅是执行功能的一个预测因素。相比之下，状态焦虑与视觉空间能力之间没有显著关系。结论：总体而言，这些发现突出表明，PD患者特定认知领域的表现与焦虑有关。因此，在诊断和治疗PD患者的痴呆症和/或轻度认知障碍时，考虑并量化焦虑对认知表现的影响可能至关重要。（《心理学文摘数据库记录》（c）2018美国心理学会，保留所有权利）
