Zis Panagiotis, Daskalaki Argyro, Bountouni Ilia, Sykioti Panagiota, Varrassi Giustino, Paladini Antonella
Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Department of Neurology, Evangelismos General Hospital, Athens, Greece.
Clin Interv Aging. 2017 Apr 21;12:709-720. doi: 10.2147/CIA.S113576. eCollection 2017.
Aging is an inevitable process and represents the accumulation of bodily alterations over time. Depression and chronic pain are highly prevalent in elderly populations. It is estimated that 13% of the elderly population will suffer simultaneously from the two conditions. Accumulating evidence suggests than neuroinflammation plays a critical role in the pathogenesis of both depression and chronic pain. Apart from the common pathophysiological mechanisms, however, the two entities have several clinical links. Their management is challenging for the pain physician; however, both pharmacologic and nonpharmacologic approaches are available and can be used when the two conditions are comorbid in the elderly patients.
衰老 是一个不可避免的过程，代表着身体变化随时间的积累。抑郁症和慢性疼痛在老年人群中非常普遍。据估计，13%的老年人口会同时患有这两种疾病。越来越多的证据表明，神经炎症在抑郁症和慢性疼痛的发病机制中都起着关键作用。然而，除了常见的病理生理机制外，这两种疾病还有几个临床关联。对于疼痛科医生来说，它们的治疗具有挑战性；不过，当老年患者同时患有这两种疾病时，可以采用药物和非药物治疗方法。
