School of Pharmacy, University of Health and Allied Sciences, Ghana.
College of Health Sciences, University of KwaZulu Natal, Durban, South Africa.
Afr Health Sci. 2020 Mar;20(1):227-237. doi: 10.4314/ahs.v20i1.28.
Despite the significant role played by vaccines in global health, concerns over vaccine safety have increased tremendously over the years. There have been occasions where vaccines have caused rare, adverse reactions some of which have led to hospitalizations and even death. It is therefore important to establish the safety profile of routinely used vaccines in order to allay fears pertaining to their use.
This review was aimed at pooling together the safety data of selected vaccines used for routine immunization in Africa, a region of the world with paucity of vaccine safety data.
Adverse Events Following Immunization safety data was searched for rotavirus, yellow fever, measles, rubella, tuberculosis (Bacillus Calmette Guerin-BCG), pneumococcal, Haemophilus Influenza type b, polio, meningococcal and the influenza A (H1N1) vaccines in PUBMED, Google Scholar, Clinical trials.gov and Cochrane controlled register of trials databases.
A total of twenty-four serious AEFIs and twenty-three minor AEFIs were identified from the review. The strength of association between AEFIs and vaccine was high for tuberculosis vaccine and moderate for all other vaccines.
Even though AEFIs (including mild and severe) were identified in the review, all the vaccines studied were generally well tolerated.
尽管疫苗在全球健康中发挥了重要作用，但多年来，人们对疫苗安全性的担忧却与日俱增。有些疫苗偶尔会引起罕见的不良反应，其中一些甚至导致住院甚至死亡。因此，重要的是要确定常规使用的疫苗的安全性概况，以消除对其使用的担忧。
本综述旨在汇集非洲常规免疫使用的选定疫苗的安全性数据，该地区疫苗安全性数据稀缺。
在 PUBMED、Google Scholar、Clinical trials.gov 和 Cochrane 对照试验注册数据库中搜索轮状病毒、黄热病、麻疹、风疹、结核（卡介苗-BCG）、肺炎球菌、流感嗜血杆菌 b 型、脊髓灰质炎、脑膜炎球菌和甲型流感（H1N1）疫苗的疫苗接种后不良事件安全性数据。
本综述共确定了 24 例严重 AEFI 和 23 例轻微 AEFI。AEFI 与疫苗之间的关联强度对于结核疫苗很高，而对于所有其他疫苗则为中度。
尽管在本综述中发现了 AEFI（包括轻度和重度），但研究中的所有疫苗通常都具有良好的耐受性。
