Kidney Care, C50, 10th B Cross, East Thillai Nagar, Tiruchirappalli-620 018, India.
Department of Medical Biochemistry, Division of Biomedical Sciences, School of Medicine, College of Health Sciences, Mekelle University (Ayder Campus), Mekelle, Ethiopia.
Afr Health Sci. 2020 Mar;20(1):308-313. doi: 10.4314/ahs.v20i1.36.
Left ventricular hypertrophy (LVH) has been proved as one among the cardiovascular complications and predominant in patients with CKD. In CKD patients, Glycated albumin (GA) express a superior marker of glycemic control than HbA1c. Nevertheless, the precision of GA for the prediction of cardiovascular diseases among the CKD population has been ineffectively reported. The present study looks at the part of GA, HbA1c in CKD to envisage vascular complications.
One hundred and ninety-four patients were selected in the present study. The study has a control group (Group I, N: 52) and participants were divided into two groups based on vein diseases (Group II, N: 42; two vessels and group III, N: 100; triple vessel disease). Serum glycated albumin, hsCRP and other routine parameters were estimated in all the three groups. 2-dimensional echocardiography (2D Echo) has been done by a cardiologist to all the study patients for assessing ejection fraction and distinguish the sort of vessel diseases.
Group I compared with group II and III shown there was a significant association among blood glucose, serum creatinine, HbA1c, mean blood glucose, GA, ejection fraction and hsCRP. Additionally, observed that increased levels of HbA1c, GA and creatinine inversely related to the left ventricle ejection fraction. Notwithstanding, GA and hsCRP predict precisely the left ventricle ejection fraction than different parameters.
GA alongside hsCRP might be appropriate markers for anticipating cardiovascular diseases particularly left ventricle hypertrophy in diabetic CKD population.
左心室肥厚（LVH）已被证明是心血管并发症之一，在 CKD 患者中较为常见。在 CKD 患者中，糖基化白蛋白（GA）比 HbA1c 更能反映血糖控制情况。然而，GA 对 CKD 人群心血管疾病的预测准确性尚未得到有效报道。本研究旨在探讨 GA、HbA1c 在 CKD 患者中的作用，以预测血管并发症。
本研究纳入了 194 名患者。研究分为对照组（I 组，N=52）和实验组（根据静脉疾病分为 II 组，N=42；两血管疾病组和 III 组，N=100；三血管疾病组）。所有三组均检测血清 GA、hsCRP 和其他常规参数。由心脏病专家对所有研究患者进行二维超声心动图（2D 回声）检查，以评估射血分数并区分血管疾病类型。
与 II 组和 III 组相比，I 组的血糖、血清肌酐、HbA1c、平均血糖、GA、射血分数和 hsCRP 之间存在显著相关性。此外，观察到 HbA1c、GA 和肌酐水平升高与左心室射血分数呈负相关。然而，GA 和 hsCRP 比其他参数更能准确预测左心室射血分数。
GA 联合 hsCRP 可能是预测糖尿病 CKD 人群心血管疾病特别是左心室肥厚的合适标志物。
