Kupersmith M J, Frohman L P, Choi I S, Foo S H, Hiesinger E, Berenstein A, Wise A, Carr R E, Ransohoff J
Department of Ophthalmology, New York University Medical School, NY.
Neurology. 1988 Feb;38(2):284-9. doi: 10.1212/wnl.38.2.284.
We studied the effects of intra-arterial chemotherapy on the visual system of 29 consecutive patients with gliomas. As expected, infra-ophthalmic carotid infusion of cisplatin or carmustine (BCNU) was associated with clinically apparent anterior visual pathway lesions. Electroretinography revealed retinal dysfunction in patients without clinical abnormalities. Supra-ophthalmic carotid infusion of cisplatin or BCNU caused no retinal or optic nerve lesions. Electroretinography was abnormal in only one of these patients. Our results indicated that BCNU and cisplatin cause ischemic damage and are toxic to both retinal and neural tissue in patients with gliomas.
我们研究了动脉内化疗对29例连续的神经胶质瘤患者视觉系统的影响。正如预期的那样，经眼动脉下方输注顺铂或卡莫司汀（BCNU）与临床上明显的视觉通路前部病变有关。视网膜电图显示，在无临床异常的患者中存在视网膜功能障碍。经眼动脉上方输注顺铂或BCNU未引起视网膜或视神经病变。这些患者中只有1例视网膜电图异常。我们的结果表明，BCNU和顺铂会造成缺血性损伤，并且对神经胶质瘤患者的视网膜和神经组织均有毒性。
