Department of Pharmacy State Hospital, Ijaye, Abeokuta, Ogun State, Nigeria.
Department of Psychiatry/Pharmacology, College of Medicine, Ekiti State University, Ado-Ekiti, Ekiti State, Nigeria.
Afr Health Sci. 2020 Sep;20(3):1206-1216. doi: 10.4314/ahs.v20i3.24.
Despite the lack of adequate studies on the safety of drugs in pregnancy, surprisingly, available evidence shows that pregnant women still take large number of drugs.
The study aim was to determine drug utilization pattern and predictors of number of medications used by pregnant women.
This was a cross-sectional survey of 369 pregnant women attending a secondary health facility. Data were collected using interviewer-administered questionnaire. Descriptive and inferential statistics using the Chi-Square test were carried out with level of significance set at p<0.05.
Three hundred and sixty-nine women were interviewed. Their mean age was 27.7 years (SD± 4.78) and the mean number of pregnancies was 2.46 (SD± 1.34). On average, 2.62 medications were taken, with the lowest being 1 and the highest being 12 different medications during the course of pregnancy. Those who were on more than 2 medications were more likely to be older than 30 years, had lower education and with history of associated medical conditions. All participants were on one form of supplements or the other, nearly half had used antimalarials, 12.8%, 5.8% 2.4% were on antibiotics, anti-hypertensive and anti-retroviral medications respectively. All the medications prescribed were from category A, B, C, N, and none from category D and X.
Varieties of medications were used during the course of pregnancy among this population, however, most of these drugs were still within safety profile.
尽管关于药物在妊娠期间安全性的研究不足,但令人惊讶的是,现有证据表明孕妇仍大量服用药物。
本研究旨在确定孕妇的用药模式和用药数量的预测因素。
这是一项对 369 名在二级医疗机构就诊的孕妇进行的横断面调查。使用访谈者管理的问卷收集数据。使用卡方检验进行描述性和推断性统计,显著性水平设为 p<0.05。
共访谈了 369 名妇女。她们的平均年龄为 27.7 岁(SD±4.78),平均妊娠次数为 2.46(SD±1.34)。平均使用了 2.62 种药物,最低为 1 种,最高为 12 种不同药物在妊娠期间。那些服用超过 2 种药物的人更可能年龄大于 30 岁,教育程度较低,并有合并症病史。所有参与者都服用了某种形式的补充剂,近一半的人使用了抗疟药,12.8%、5.8%和 2.4%的人分别使用了抗生素、抗高血压药和抗逆转录病毒药物。所有开的药都属于 A、B、C、N 类,没有 D 类和 X 类。
在这一人群中,在妊娠期间使用了各种药物,但大多数这些药物仍在安全范围内。