Potchoo Yao, Redah Datouda, Gneni Malick A, Guissou Innocent P
Faculty of Medicine and Pharmacy, University of Lome, Lome, BP 1515, Togo.
Eur J Clin Pharmacol. 2009 Aug;65(8):831-8. doi: 10.1007/s00228-009-0644-5. Epub 2009 Apr 1.
To assess the trends in prescription drugs and the potential repercussions to newborns among pregnant women who attended prenatal consultations and gave birth in the Department of Gynaecology of Tokoin's University Hospital, Lome (Togo).
A retrospective study of the registers of prenatal visits and deliveries of the eligible population was performed.
In total, 184 different drugs were prescribed to 627 pregnant women attending prenatal consultations. The profile of pharmacotherapeutic groups prescribed was: anti-anaemics (33.33%), antimalarial drugs (24.75%), vitamins +/- mineral salts, amino acids and appetite stimulants (14.96%) and antispasmodics and anti-emetics (7.22%). The median proportion of prescriptions for each pharmacotherapeutic group increased significantly from the first to third trimester (9.72, 25.17 and 64.00 respectively; P < 0.05). The median number of drugs prescribed did not vary significantly (P = 0.051) with the age groups, parity (P = 0.068) or obstetrical-gynaecological history (P = 0.401); it did, however, increase significantly with the medical-surgical history (P < 0.05). There were complications associated with deliveries that had no obvious cause related to drug prescription, including four cases of minor defects, 28 stillborns, 65 cases of low birth weight and 27 hospitalised newborns for neonatal diseases. Some interventions were needed for safeguarding the health of the mother, the foetus and the newborn.
The trends in obtaining prescription drugs and the consumption of drugs by pregnant women can be assessed using multiple parameters. We limited our study to age groups, gestational age, parity and the medical history of the pregnant woman, profile of pharmacotherapeutic groups, median number of drugs prescribed and the potential risks of the drugs used. The results of our retrospective study were not alarming in terms of neonatal outcomes.
评估在多哥洛美托科因大学医院妇科进行产前咨询并分娩的孕妇中处方药的使用趋势以及对新生儿的潜在影响。
对符合条件人群的产前检查和分娩记录进行回顾性研究。
总共为627名进行产前咨询的孕妇开具了184种不同的药物。所开药物治疗组的情况如下：抗贫血药（33.33%）、抗疟药（24.75%）、维生素±矿物质盐、氨基酸和食欲刺激剂（14.96%）以及解痉药和止吐药（7.22%）。每个药物治疗组的处方中位数比例从孕早期到孕晚期显著增加（分别为9.72、25.17和64.00；P<0.05）。所开药物的中位数在不同年龄组、产次（P = 0.068）或妇产科病史（P = 0.401）之间无显著差异；然而，在有内科/外科病史的孕妇中显著增加（P<0.05）。分娩存在与药物处方无明显关联的并发症，包括4例轻微缺陷、28例死产、65例低体重儿以及27例因新生儿疾病住院的新生儿。需要采取一些干预措施来保障母亲、胎儿和新生儿的健康。
可使用多个参数评估孕妇获取处方药的趋势和用药情况。我们的研究局限于孕妇的年龄组、孕周、产次和病史、药物治疗组情况、所开药物的中位数以及所用药物的潜在风险。就新生儿结局而言，我们的回顾性研究结果并不令人担忧。
