Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Afr Health Sci. 2020 Sep;20(3):1329-1336. doi: 10.4314/ahs.v20i3.39.
Type 2 diabetes mellitus (T2DM) considered as one of the cardiovascular disorders (CVD) principle risk factor as diabetes is associated with abnormal levels of endothelial function, inflammatory and adipocytokines.
The aim of this study was to measure the impact of weight reducing on inflammatory cytokines, adipocytokines and endothelial function biomarkers among obese T2DM patients.
One-hundred T2DM patients enrolled in the present study; the age range was 35-55 year. Participants shared in this study were enrolled in group (A) received diet control and aerobic exercise on treadmill, while, group (B) had no intervention for 3 months.
The mean values of body mass index (BMI), tumor necrosis factor -alpha (TNF-α), interleukin-6 (IL-6), leptin, inter-cellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1), E-selectin and plasminogen activator inhibitor-1 activity (PAI-1 activity) were significantly decreased and adiponectin was increased significantly in the training group, however the results of the control group were not significant. Also, there were significant differences between both groups at the end of the study.
Weight reducing program modulates inflammatory cytokines, adipocytokines and endothelial function biomarkers among obese T2DM patients.
2 型糖尿病（T2DM）被认为是心血管疾病（CVD）的主要危险因素之一，因为糖尿病与内皮功能、炎症和脂肪细胞因子的异常水平有关。
本研究旨在测量减肥对肥胖 2 型糖尿病患者的炎症细胞因子、脂肪细胞因子和内皮功能生物标志物的影响。
本研究纳入了 100 名 2 型糖尿病患者，年龄在 35-55 岁之间。参与者被分为两组：A 组接受饮食控制和跑步机有氧运动，B 组在 3 个月内不进行任何干预。
训练组的体重指数（BMI）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、瘦素、细胞间黏附分子（ICAM-1）、血管细胞黏附分子（VCAM-1）、E-选择素和纤溶酶原激活物抑制剂-1 活性（PAI-1 活性）的平均值显著降低，脂联素显著增加，而对照组的结果则不显著。此外，研究结束时两组之间存在显著差异。
减肥计划可调节肥胖 2 型糖尿病患者的炎症细胞因子、脂肪细胞因子和内皮功能生物标志物。
