Anandaraj Antony A, Syed Ismail Prabu Mahin, Namis Sultan Mohammed, Bajnaid Youssef Jadallah, Shetty Sapna B, Almutairi Khalid M
Clinical Teaching Fellow, St. George's University School of Medicine, Department of pathology, True Blue, St. Georges, Grenada, West Indies. 0.
Department of Conservative Dentistry and Endodontics, Ibn Sina National College for Medical Studies, Jeddah,. Saudi Arabia.
Curr Diabetes Rev. 2017;13(3):330-335. doi: 10.2174/1573399812666160614014254.
In this prospective study, we establishing the association of obesity in type 2 diabetes patients with various inflammatory markers and adipocytokines, as risk factors for cardiovascular disease (CVD).
In this work, a total of 85 individuals gave concern and were divided into 4 groups based on their body mass indices (BMI). Anthropometrics details were obtained from each individual and different laboratory tests were performed to measure levels of adipocytokines such as adiponectin, leptin and resistin and inflammatory markers such as TNF-α, IL-6 and hsCRP. All the 82 patients with T2D were studied in four groups, A includes obese with BMI >30 kg/m2, B includes overweight with BMI ranging 25 to 30 kg/m2), C includes non-obese with BMI < 25 kg/m2. Group D was control, included non-obese (BMI < 25 kg/m2) and non-diabetic individuals. Result & Discussion: There was an increase in plasma insulin levels in T2D patients, especially with exhibiting high BMI and diabetic conditions in Group A. Adiponectin was higher in the control group which is significant with the value of p<0.05 compared to other three groups. There was negative correlation observed found to be significant, between obesity and adiponectin. Positive correlation was seen among leptin, resistin and inflammatory markers among T2D and control individuals which were significant. T2D groups had an increase in plasma insulin and adiponectin, but decreased leptin, resistin and inflammatory markers compared to control. Overall, T2D patients showed a significant correlation between plasma insulin, adipocytokines and other inflammatory markers clearly designate the impact of metabolic conditions such as obesity on these factors and vice versa. Increased levels of the parameters restrained in the study correlate T2D and obesity to cardiovascular diseases.
在这项前瞻性研究中，我们确定2型糖尿病患者的肥胖与各种炎症标志物和脂肪细胞因子之间的关联，将其作为心血管疾病（CVD）的危险因素。
在本研究中，共有85人参与，根据他们的体重指数（BMI）分为4组。从每个人那里获取人体测量学细节，并进行不同的实验室测试，以测量脂联素、瘦素和抵抗素等脂肪细胞因子以及肿瘤坏死因子-α、白细胞介素-6和高敏C反应蛋白等炎症标志物的水平。所有82例2型糖尿病患者分为四组，A组包括BMI>30 kg/m²的肥胖患者，B组包括BMI在25至30 kg/m²之间的超重患者，C组包括BMI<25 kg/m²的非肥胖患者。D组为对照组，包括非肥胖（BMI<25 kg/m²）且非糖尿病个体。结果与讨论：2型糖尿病患者的血浆胰岛素水平升高，尤其是A组中BMI高且患有糖尿病的患者。对照组的脂联素水平较高，与其他三组相比，p值<0.05，差异具有统计学意义。肥胖与脂联素之间存在显著的负相关。在2型糖尿病患者和对照组个体中，瘦素、抵抗素与炎症标志物之间存在显著的正相关。与对照组相比，2型糖尿病组的血浆胰岛素和脂联素升高，但瘦素、抵抗素和炎症标志物降低。总体而言，2型糖尿病患者的血浆胰岛素、脂肪细胞因子与其他炎症标志物之间存在显著相关性，清楚地表明肥胖等代谢状况对这些因素的影响，反之亦然。研究中所检测参数水平的升高将2型糖尿病和肥胖与心血管疾病联系起来。
