一个西班牙裔家庭中的家族性脑海绵状血管瘤
Familial cavernous angiomas of the brain in an Hispanic family.
作者信息
Mason I, Aase J M, Orrison W W, Wicks J D, Seigel R S, Bicknell J M
机构信息
Department of Neurology, University of New Mexico School of Medicine, Albuquerque 87131.
出版信息
Neurology. 1988 Feb;38(2):324-6. doi: 10.1212/wnl.38.2.324.
We found cavernous angiomas (CA) in 10 of 22 members of a large Hispanic family. The proband had seizures, and a CA was found at surgery. He and two sisters with seizures had normal angiograms, but CT or MRI showed lesions compatible with CA. Similar abnormalities were found in two cousins with seizures and 5 of 17 asymptomatic relatives studied. MRI proved to be more sensitive than CT for identifying CA. Hispanic families appear to have a predisposition for dominantly inherited CA of the brain.
我们在一个庞大的西班牙裔家族的22名成员中发现了10例海绵状血管瘤（CA）。先证者有癫痫发作，手术时发现了一个CA。他和另外两名有癫痫发作的姐妹血管造影正常，但CT或MRI显示有与CA相符的病变。在两名有癫痫发作的表亲和17名接受研究的无症状亲属中的5名中也发现了类似异常。MRI在识别CA方面被证明比CT更敏感。西班牙裔家族似乎易患大脑中以显性方式遗传的CA。
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