血清氟与膝关节骨关节炎关系的临床及影像学研究
Clinical and Radiological Study of Serum Fluoride in Relation to Knee Osteoarthritis.
作者信息
Singh V K, Rathore K S, Khan G, Rahim A, Rashid A, Chauhan S
机构信息
Department of Orthopaedics, NIMS Medical College and Hospital, Jaipur, India.
出版信息
Malays Orthop J. 2020 Nov;14(3):151-154. doi: 10.5704/MOJ.2011.023.
INTRODUCTION
Fluorosis has been associated with an increased risk of degenerative changes in the knee. Multiple studies have found an association between arthritis and elevated fluoride levels. We aim to delineate if elevated fluoride level has any direct correlation with the degree of radiological grading and clinical symptoms in knee arthritis.
MATERIALS AND METHODS
A cross-sectional study of 80 knee arthritis patients was conducted from February 2017 to April 2018. Serum fluoride levels were measured and patient's pain scores, WOMAC scores and radiological grading were correlated with the elevated fluoride levels.
RESULTS
In our study, 30 out of 80 patients had increased serum fluoride level. Statistically significant differences were noted in VAS score, WOMAC score and Kellgren and Lawrence radiological grades between patients with normal serum fluoride level and those with elevated fluoride level.
CONCLUSION
There is an increased risk of knee arthritis in patients with elevated blood fluoride levels and patients with increased fluoride levels are associated with more severe symptoms and radiographic disease.
引言
氟中毒与膝关节退行性变风险增加有关。多项研究发现关节炎与氟水平升高之间存在关联。我们旨在确定氟水平升高是否与膝关节炎的放射学分级程度和临床症状有直接相关性。
材料与方法
2017年2月至2018年4月对80例膝关节炎患者进行了一项横断面研究。测量血清氟水平，并将患者的疼痛评分、WOMAC评分和放射学分级与氟水平升高情况进行关联分析。
结果
在我们的研究中，80例患者中有30例血清氟水平升高。血清氟水平正常的患者与氟水平升高的患者在视觉模拟评分（VAS）、WOMAC评分以及凯尔格伦和劳伦斯放射学分级方面存在统计学显著差异。
结论
血氟水平升高的患者患膝关节炎的风险增加，且氟水平升高的患者症状更严重，放射学疾病更明显。
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