U-Vet Animal Hospital, University of Melbourne, Werribee, VIC, 3030, Australia.
Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Werribee, VIC, 3030, Australia.
J Small Anim Pract. 2021 Feb;62(2):114-122. doi: 10.1111/jsap.13260. Epub 2021 Jan 5.
Cytological biopsies are an integral additional test to an abdominal ultrasound when a lesion is identified, but there is little published on factors that that may impact achieving a clinically useful sample of gastrointestinal lesions obtained by ultrasound-guided fine-needle cytologic biopsy. This retrospective, descriptive study aimed to assess factors that may influence the clinical usefulness of submitted cytological samples collected from gastrointestinal lesions by ultrasound-guided percutaneous fine-needle cytologic biopsy.
Gastrointestinal cytological samples obtained from 25 dogs and 19 cats over 2.5 years were reviewed and determined as clinically useful or clinically useless as per the cytology report. Variables dependent on the ultrasound exam that were used in the analysis included lesion location, lesion thickness, loss of gastrointestinal layering, and the number of slides submitted.
Thirty (30/44) of the submitted cytological samples were considered clinically useful. Factors associated with achieving a clinically useful sample in univariable models included the number of slides submitted and the thickness of the lesion. However, these two variables appear inter-related, as a weak correlation existed between them. Where histologic biopsies were obtained, a clinically useful sample had a partial or complete agreement with histology in three of 12 and eight of 12 cases, respectively.
Ultrasound-guided fine-needle cytological biopsies of gastrointestinal masses provided a clinically useful sample in two-third of the cases, especially if more slides were provided to the cytologist and thicker lesions were sampled.
当发现病变时，细胞学活检是腹部超声检查的一个重要补充，但关于可能影响通过超声引导下细针细胞学活检获得胃肠道病变有临床意义样本的因素，发表的文献较少。本回顾性描述性研究旨在评估可能影响超声引导经皮细针细胞学活检胃肠道病变采集的细胞学样本临床有用性的因素。
回顾了 2.5 年内 25 只狗和 19 只猫的胃肠道细胞学样本，并根据细胞学报告确定为临床有用或临床无用。分析中使用的依赖于超声检查的变量包括病变位置、病变厚度、胃肠道分层丧失和提交的载玻片数量。
30/44 份提交的细胞学样本被认为具有临床意义。在单变量模型中，与获得临床有用样本相关的因素包括提交的载玻片数量和病变厚度。然而，这两个变量似乎相互关联，因为它们之间存在弱相关。在获得组织学活检的情况下，12 个病例中的 3 个和 12 个病例中的 8 个的临床有用样本与组织学具有部分或完全一致性。
胃肠道肿块的超声引导下细针细胞学活检在三分之二的病例中提供了具有临床意义的样本，尤其是当向细胞学专家提供更多的载玻片并对较厚的病变进行采样时。
