STI/HIV Unit, San Gallicano Dermatological Institute IRCCS, Rome 00144, Italy.
Department of Pathology, Regina Elena National Cancer Institute IRCCS, Rome 00144, Italy.
Future Microbiol. 2020 Dec;15:1713-1722. doi: 10.2217/fmb-2020-0186. Epub 2021 Jan 6.
Men who have sex with men (MSM) harbor a significant burden of human papillomavirus (HPV)-related diseases that could be prevented by vaccination. Prevalence of HPVs targeted by the quadrivalent (4vHPV) and nonavalent vaccines (9vHPV) was assessed in anal (n = 443) and oral (n = 193) specimens of immunocompetent, sexually active MSM, using the Linear Array. Of the anal samples, 34.1 and 46.0% were positive for at least one genotype of those covered by the 4vHPV and 9vHPV, respectively. At least one of the HPVs targeted by the 9vHPV was detected in 5.7% of the oral specimens. The majority of the subjects were not currently infected by HPV-16 and other vaccine-preventable HPVs. Universal HPV vaccination should be strongly promoted in order to achieve protection for all risk groups. In the meanwhile, vaccination should be offered to sexually active adult MSM attendees of sexually transmitted infection centers, although its potential benefit for these subjects needs to be further investigated.
男男性行为者（MSM）患有与人类乳头瘤病毒（HPV）相关的疾病，其负担沉重，而疫苗接种可以预防这些疾病。本研究使用线性阵列技术，评估了 443 名免疫功能正常的活跃 MSM 的肛门样本和 193 名口腔样本中，四价（4vHPV）和九价（9vHPV）疫苗针对的 HPV 的流行情况。在肛门样本中，分别有 34.1%和 46.0%的样本至少感染了一种 4vHPV 和 9vHPV 疫苗涵盖的基因型。在 5.7%的口腔样本中检测到至少一种 9vHPV 疫苗针对的 HPV。大多数研究对象目前并未感染 HPV-16 和其他可通过疫苗预防的 HPV。为了保护所有的高危人群，应该大力推广 HPV 疫苗的普遍接种。同时，应该为性传播感染中心的活跃 MSM 性活跃成年人提供疫苗接种，但需要进一步研究其对这些人群的潜在益处。
