Suppr超能文献

总斑块面积和斑块回声强度是系统性红斑狼疮患者亚临床动脉粥样硬化的新指标。

Total plaque area and plaque echogenicity are novel measures of subclinical atherosclerosis in patients with systemic lupus erythematosus.

机构信息

Division of Medicine, Centre for Rheumatology Research, University College London.

Vascular Screening and Diagnostic Centre, London, UK.

出版信息

Rheumatology (Oxford). 2021 Sep 1;60(9):4185-4198. doi: 10.1093/rheumatology/keaa905.

Abstract

OBJECTIVES

Patients with SLE have an increased risk of developing cardiovascular disease (CVD). Multiple studies have shown that these patients have increased numbers of carotid plaques and greater intima-media thickness (IMT) than healthy controls. Measures such as total plaque area (TPA) and plaque echogenicity may be more sensitive and more relevant to cardiovascular risk than presence of plaque and IMT alone. Our objective was to produce the first report of TPA and echogenicity in a population of patients with SLE.

METHODS

One hundred patients with SLE and no history of clinical CVD were recruited. Clinical, serological and treatment variables were recorded and serum was tested for antibodies to apolipoprotein A-1 and high-density lipoprotein. Both carotid and both femoral artery bifurcations of each patient were scanned to determine IMT, TPA and echogenicity of plaques. Univariable and multivariable statistical analyses were carried out to define factors associated with each of these outcomes.

RESULTS

Thirty-six patients had carotid and/or femoral plaque. Increasing age was associated with presence of plaque and increased IMT. Triglyceride levels were associated with presence of plaque. Mean (s.d.) TPA was 60.8 (41.6) mm2. Patients taking prednisolone had higher TPA. Most plaques were echolucent, but increased echogenicity was associated with prednisolone therapy and persistent disease activity.

CONCLUSION

TPA and plaque echogenicity in patients with SLE are associated with different factors than those associated with presence of plaque and IMT. Longitudinal studies may show whether these outcome measures add value in the management of cardiovascular risk in SLE.

摘要

目的

患有系统性红斑狼疮(SLE)的患者发生心血管疾病(CVD)的风险增加。多项研究表明,这些患者的颈动脉斑块数量和内膜中层厚度(IMT)均高于健康对照者。总斑块面积(TPA)和斑块回声特征等指标可能比斑块和 IMT 本身更敏感,与心血管风险更相关。我们的目的是首次报告 SLE 患者群体中的 TPA 和回声特征。

方法

招募了 100 名无临床 CVD 病史的 SLE 患者。记录临床、血清学和治疗变量,并检测血清载脂蛋白 A-1 和高密度脂蛋白抗体。对每位患者的双侧颈动脉和双侧股动脉分叉处进行扫描,以确定 IMT、TPA 和斑块回声特征。进行单变量和多变量统计分析,以确定与这些结果相关的因素。

结果

36 名患者存在颈动脉和/或股动脉斑块。年龄增长与斑块和 IMT 增加相关。甘油三酯水平与斑块存在相关。平均(标准差)TPA 为 60.8(41.6)mm2。服用泼尼松龙的患者 TPA 更高。大多数斑块为低回声,但回声增强与泼尼松龙治疗和持续的疾病活动有关。

结论

SLE 患者的 TPA 和斑块回声特征与与斑块和 IMT 相关的因素不同。纵向研究可能表明这些结局指标是否在 SLE 患者心血管风险管理中具有附加价值。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验