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胃食管反流病和/或食管裂孔疝患者的单吻合口胃旁路手术。

One Anastomosis Gastric Bypass in Patients with Gastrooesophageal Reflux Disease and/or Hiatus Hernia.

机构信息

Bariatric Unit, Sunderland Royal Hospital, Sunderland, SR4 7TP, UK.

University of Sunderland, Sunderland, UK.

出版信息

Obes Surg. 2021 Apr;31(4):1449-1454. doi: 10.1007/s11695-020-05149-0. Epub 2021 Jan 6.

Abstract

INTRODUCTION

One anastomosis gastric bypass (OAGB) offers favourable weight loss outcomes and is associated with reduced morbidity and mortality when compared to other mainstream bariatric procedures. However, a randomised trial reported a conversion rate to roux-en-Y configuration (RYC) of 3.1%, and some surgeons consider the procedure unsuitable for patients with a preoperative hiatus hernia (HH) or symptoms of gastrooesophageal reflux disease (GORD).

METHODS

We carried out a retrospective review of patients undergoing OAGB in our institution. Included were all patients on PPI for symptoms of GORD preoperatively, as well as patients with HH or oesophagitis on preoperative endoscopy. We recorded GORD outcomes as well as rates of conversion to RYC in patients.

RESULTS

Medium term follow up data at 23-28 months was available for 89 patients. Of these, 63 had HH, 34 had preoperative GORD requiring PPI and 9 had confirmed oesophagitis. The conversion rate to RYC was nil (0/63) in patients with HH. At the same time, 14.7% (5/34) of patients with preop GORD on PPI required conversion to RYC at a median time interval of 16 months. In patients already on PPI preoperatively, 16/34 (47.1%) needed to continue on PPI long term. In patients with HH, 20.6% (13/63) suffered de novo GORD symptoms.

CONCLUSION

OAGB can be offered to patients with HH with acceptable GORD outcomes but caution is advised in patients with preoperative GORD symptoms. Larger prospective and randomised studies are required to further assess this subgroup.

摘要

介绍

与其他主流减重手术相比,单吻合口胃旁路术(OAGB)可实现更优的减重效果,且与更低的发病率和死亡率相关。然而,一项随机试验报告其转为 Roux-en-Y 构型(RYC)的转化率为 3.1%,且一些外科医生认为该手术不适合术前存在食管裂孔疝(HH)或胃食管反流病(GORD)症状的患者。

方法

我们对在我院行 OAGB 的患者进行了回顾性研究。所有术前因 GORD 症状服用质子泵抑制剂(PPI)的患者以及术前胃镜检查有 HH 或食管炎的患者均被纳入研究。我们记录了 GORD 结局以及患者转为 RYC 的发生率。

结果

89 例患者可获得 23-28 个月的中期随访数据。其中 63 例有 HH,34 例术前 GORD 需要 PPI 治疗,9 例有确诊的食管炎。有 HH 的患者转为 RYC 的转化率为零(0/63)。与此同时,术前 PPI 治疗的 GORD 患者中有 14.7%(5/34)在中位 16 个月时需要转为 RYC。术前已服用 PPI 的患者中,16/34(47.1%)需要长期服用 PPI。有 HH 的患者中,20.6%(13/63)出现新发 GORD 症状。

结论

OAGB 可用于 HH 患者,GORD 结局可接受,但对于术前 GORD 症状的患者应谨慎。需要更大规模的前瞻性和随机研究来进一步评估这一亚组患者。

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