Yıldız Fatih, Gökmen Onur
Department of Rheumatology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
Department of Ophthalmology, Health Sciences University, Van Training and Research Hospital, Van, Turkey.
Int J Clin Pract. 2021 Mar;75(3):e13992. doi: 10.1111/ijcp.13992. Epub 2021 Jan 19.
The present study was conducted to investigate the association between haematologic indices, neutrophil/lymphocyte ratio (NLR), mean platelet volume (MPV), platelet/lymphocyte ratio (PLR), disease activation, organ involvement, and inflammatory markers in the SS.
The study was conducted with newly diagnosed and treatment-naive 41 primary SS patients who met ACR-2012 criteria and 96 healthy volunteers. Blood tests obtained before treatment were evaluated. Lymphocyte, neutrophil and platelet counts, mean corpuscular volume (MCV), platelet distribution width (PDW), plateletcrit (PCT), haematocrit (HCT), MPV, white blood cell count (WBC) values were harvested from CBC of the subjects and NLR, PLR were calculated over these values. The values were compared between groups and correlation with EULAR SS disease activity index (ESSDAI) was evaluated.
The study included a total of 41 patients with a mean age of 40.73 ± 12.0 years and 96 healthy subjects with a mean age of 40.0 ± 9.2 years. In inter-group comparisons, lymphocyte, platelet counts, and MPV values were significantly lower in the SS group compared with the control group (P < .01), and NLR was significantly higher in the SS group (P = .026). The mean ESSDAI scores in SS patients were 5.65 ± 0.86 SE. These scores were significantly higher in patients with neurological involvement. There was a positive correlation between ESSDAI and PLR.
NLR, PLR, and MPV may be used as indicators or with activity index in SS. ESSDAI scores were found to be high in patients with neurological involvement, and it was also found to be correlated with PLR.
本研究旨在调查血液学指标、中性粒细胞/淋巴细胞比值（NLR）、平均血小板体积（MPV）、血小板/淋巴细胞比值（PLR）、疾病活动度、器官受累情况以及干燥综合征（SS）中的炎症标志物之间的关联。
该研究纳入了41例符合美国风湿病学会（ACR）2012标准的初诊且未接受过治疗的原发性SS患者以及96名健康志愿者。对治疗前进行的血液检查结果进行评估。从受试者的全血细胞计数（CBC）中获取淋巴细胞、中性粒细胞和血小板计数、平均红细胞体积（MCV）、血小板分布宽度（PDW）、血小板压积（PCT）、血细胞比容（HCT）、MPV、白细胞计数（WBC）值，并基于这些值计算NLR和PLR。对两组间的这些值进行比较，并评估其与欧洲抗风湿病联盟（EULAR）SS疾病活动指数（ESSDAI）的相关性。
该研究共纳入41例患者，平均年龄为40.73±12.0岁，以及96名健康受试者，平均年龄为40.0±9.2岁。在组间比较中，SS组的淋巴细胞、血小板计数和MPV值显著低于对照组（P<0.01），而SS组的NLR显著更高（P = 0.026）。SS患者的平均ESSDAI评分为5.65±0.86标准误。神经系统受累患者的这些评分显著更高。ESSDAI与PLR之间存在正相关。
NLR、PLR和MPV可作为SS的指标或与活动指数一起使用。发现神经系统受累患者的ESSDAI评分较高，并且还发现其与PLR相关。
