Sargin Gokhan, Demir Ceren, Cildag Songül, Senturk Taskin
Department of Rheumatology, Medical Faculty, Aydin Adnan Menderes University, Turkey.
Reumatologia. 2022;60(5):351-356. doi: 10.5114/reum.2022.120760. Epub 2022 Nov 4.
Muscle enzymes are an indicator of ongoing muscle damage and disease activity in patients with idiopathic inflammatory myopathy. Although platelet-related parameters have been shown to be useful as markers of disease activity in autoimmune diseases, the relationship between platelet distribution width (PDW) and disease activity has not been previously studied in polymyositis. We aimed to determine the relationship between PDW and disease activity in patients with polymyositis.
Twenty-seven patients with polymyositis and thirty healthy controls were included in the study. Disease activity was evaluated using the myositis disease activity assessment Visual Analogue Scale (MYOACT) and the Myositis Intention to Treat Index (MITAX). The relationship between PDW and disease activity was evaluated using Pearson's or Spearman's correlation and reliability was assessed using correlation coefficients.
The mean platelet volume (MPV) and plateletcrit (PCT) were significantly higher and PDW was significantly lower in patients with polymyositis compared to the control group. The mean PDW levels were lower in patients with constitutional symptoms and arthralgia/arthritis ( < 0.005). Although PDW levels were lower in patients with mechanical hand, lung involvement, or dysphagia compared to patients without, there was no statistically significant difference between them. Platelet distribution width was found to be negatively correlated with disease activity.
We found that PDW was negatively correlated with MYOACT and MITAX, widely used tools in assessing the disease activity of polymyositis. Based on this, PDW may be utilized as a non-invasive potential index to assess disease activity in patients with polymyositis.
肌肉酶是特发性炎性肌病患者持续肌肉损伤和疾病活动的一个指标。尽管血小板相关参数已被证明可作为自身免疫性疾病疾病活动的标志物，但血小板分布宽度（PDW）与疾病活动之间的关系此前尚未在多发性肌炎中进行研究。我们旨在确定多发性肌炎患者中PDW与疾病活动之间的关系。
本研究纳入了27例多发性肌炎患者和30名健康对照者。使用肌炎疾病活动评估视觉模拟量表（MYOACT）和肌炎意向性治疗指数（MITAX）评估疾病活动。使用Pearson或Spearman相关性评估PDW与疾病活动之间的关系，并使用相关系数评估可靠性。
与对照组相比，多发性肌炎患者的平均血小板体积（MPV）和血小板压积（PCT）显著更高，而PDW显著更低。有全身症状和关节痛/关节炎的患者平均PDW水平更低（<0.005）。尽管与无机械性手部症状、肺部受累或吞咽困难的患者相比，有这些症状的患者PDW水平更低，但它们之间无统计学显著差异。发现血小板分布宽度与疾病活动呈负相关。
我们发现PDW与MYOACT和MITAX呈负相关，这两个是评估多发性肌炎疾病活动的广泛使用的工具。基于此，PDW可作为评估多发性肌炎患者疾病活动的一种非侵入性潜在指标。
