Department of Pathology, Bezmialem Vakif University, Medical Faculty, Istanbul, Turkey.
Department of Pathology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey ; and.
Am J Dermatopathol. 2021 Mar 1;43(3):198-201. doi: 10.1097/DAD.0000000000001743.
Proliferating pilar tumor (PPT) is an adnexal tumor of purported differentiation toward the follicular outer root sheath. Immunohistochemistry has been suggested to differentiate between benign and malignant forms.
Eleven benign (PPT) and 9 malignant PPT lesions were reviewed; Ki67, p27, and p53 were applied. The staining intensity (strong, moderate, weak, and negative), positive cell numbers, and marker indexes (%) were scored using image-analysis software (ViraSoft).
Overall, there was no significant correlation between Ki67 and p53 and histopathological features. However, malignant PPTs had significantly lower numbers of p27-positive cells (P = 0.030).
Our study includes the largest group of patients in whom image analysis of p53, Ki67, and p27 has been used to try to separate benign from malignant lesions. Although there were no significant differences regarding Ki67 and p53, malignant lesions have a statistically lower expression of p27. Further studies may be needed to determine the clinical usefulness of image analysis in this differential diagnosis.
增生性毛囊瘤（PPT）是一种被认为分化为毛囊外根鞘的附属肿瘤。免疫组织化学已被建议用于区分良性和恶性形式。
回顾了 11 例良性（PPT）和 9 例恶性 PPT 病变；应用 Ki67、p27 和 p53。使用图像分析软件（ViraSoft）对染色强度（强、中、弱和阴性）、阳性细胞数量和标记指数（%）进行评分。
总体而言，Ki67 和 p53 与组织病理学特征之间没有显著相关性。然而，恶性 PPT 中 p27 阳性细胞的数量明显减少（P = 0.030）。
我们的研究包括了使用 p53、Ki67 和 p27 的图像分析来尝试区分良性和恶性病变的最大患者群体。尽管 Ki67 和 p53 没有显著差异，但恶性病变的 p27 表达明显降低。可能需要进一步的研究来确定图像分析在这种鉴别诊断中的临床实用性。
