From the Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, Malmö, Sweden.
Dermatovenerology and Allergy Centre, Odense University Hospital, University of Southern Denmark.
Dermatitis. 2021;32(4):220-224. doi: 10.1097/DER.0000000000000657.
In the early 1980s, a preservative containing a mixture of methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) in a ratio of 3:1 was introduced. This mixture (mix) has been patch tested at 100 ppm (0.01%) worldwide and at 200 ppm (0.02%) in Sweden since 1986 and also in the European baseline series since 2014.
A new aqueous mix of MCI 0.015% and MI 0.2% was compared with patch testing with the 2 aqueous baseline preparations of MCI/MI 0.02% and MI 0.2%.
Four thousand three hundred ninety-seven patients with dermatitis in 12 International Contact Dermatitis Research Group dermatology departments from 3 continents were patch tested simultaneously with the 3 preparations.
The frequency of positive patch tests to the allergens varied between 0% and 26.7% in the 12 test centers. The new mixture MCI/MI 0.215% in aqua (aq) detected significantly more patients with MCI/MI allergy than both MCI/MI 0.02% aq (P < 0.001) and MI 0.2% aq (P < 0.001) alone and combined.
The results favor replacing the preparations MCI/MI 0.02% aq and MI 0.2% aq with the mixture MCI/MI 0.215% aq in the International Contact Dermatitis Research Group baseline series.
20 世纪 80 年代初，引入了一种含有甲基氯异噻唑啉酮（MCI）和甲基异噻唑啉酮（MI）混合物的防腐剂，比例为 3:1。自 1986 年以来，这种混合物（混合）在全球的 100ppm（0.01%）和瑞典的 200ppm（0.02%）进行了斑贴试验，并且自 2014 年以来也在欧洲基线系列中进行了斑贴试验。
将新的 MCI 0.015%和 MI 0.2%的水性混合物与 MCI/MI 0.02%和 MI 0.2%的 2 种水性基线制剂的斑贴试验进行比较。
来自 3 大洲的 12 个国际接触性皮炎研究组皮肤科的 4397 名皮炎患者同时接受了这 3 种制剂的斑贴试验。
在 12 个试验中心，过敏原的阳性斑贴试验频率在 0%至 26.7%之间变化。新的 MCI/MI 0.215%水性混合物比 MCI/MI 0.02%水性混合物（P<0.001）和 MI 0.2%水性混合物（P<0.001）单独和联合检测到更多的 MCI/MI 过敏患者。
结果倾向于用 MCI/MI 0.215%水性混合物替代 MCI/MI 0.02%水性混合物和 MI 0.2%水性混合物，用于国际接触性皮炎研究组的基线系列。
