Engfeldt Malin, Bråred-Christensson Johanna, Isaksson Marléne, Matura Mihály, Ryberg Kristina, Stenberg Berndt, Svedman Cecilia, Bruze Magnus
Department of Occupational and Environmental Dermatology, Skåne University Hospital, Malmö, Lund University, Jan Waldenströmsgata 16, SE-20502 Malmö, Sweden.
Acta Derm Venereol. 2015 Jul;95(6):717-9. doi: 10.2340/00015555-2029.
The preservative methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) is a well-known sensitiser and present in the Swedish baseline series since the 1980s. The proportions of MCI/MI are 3:1. MI alone has been used as a preservative since less than 10 years. This study was conducted on behalf of the Swedish Contact Dermatitis Research Group to evaluate inclusion of MI in the Swedish baseline series since the preparation of MCI/MI might fail to detect contact-allergic reactions to MI alone. Patients with suspected allergic contact dermatitis at 5 Swedish dermatology departments were consecutively patch tested with MI 2,000 ppm aq and MCI/MI 200 ppm aq. The number of cases with exclusive contact allergy to MI varied between 0.8-4.2%. In total, 1.9% reacted exclusively to MI and not to MCI/MI. Due to the considerable frequency of contact allergy to MI not traced by MCI/MI, MI 2,000 ppm aq is included in the Swedish baseline series from January 2014. This corresponds to a dose of 60 μg/cm2.
防腐剂甲基氯异噻唑啉酮/甲基异噻唑啉酮（MCI/MI）是一种知名的致敏剂，自20世纪80年代以来就存在于瑞典基线系列中。MCI/MI的比例为3:1。单独使用MI作为防腐剂的时间不到10年。这项研究是代表瑞典接触性皮炎研究小组进行的，目的是评估将MI纳入瑞典基线系列，因为制备MCI/MI可能无法检测到单独对MI的接触过敏反应。瑞典5个皮肤科部门疑似过敏性接触性皮炎的患者连续接受2000 ppm水溶液的MI和200 ppm水溶液的MCI/MI斑贴试验。仅对MI有接触过敏的病例数在0.8%-4.2%之间。总体而言，1.9%的患者仅对MI有反应，而对MCI/MI无反应。由于MCI/MI未检测到的对MI接触过敏的频率相当高，自2014年1月起，2000 ppm水溶液的MI被纳入瑞典基线系列。这相当于60μg/cm²的剂量。
