Zhou You, Gui Qinyuan, Yu Wenyuan, Liao Shenglong, He Yonglin, Tao Xinglei, Yu Yang, Wang Yapei
Department of Chemistry, Renmin University of China, Beijing 100872, China.
Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
ACS Biomater Sci Eng. 2019 Nov 11;5(11):6311-6318. doi: 10.1021/acsbiomaterials.9b01293. Epub 2019 Oct 6.
Despite great progresses in bioprinting materials and technologies, immense challenges still remain when printing tubular tissues or organs with satisfying mechanical and chemical properties, such as blood vessel, colon, and trachea. Herein, a promising extrusion system based on an interfacial diffusion printing (IDP) technique for one-step printing of tubular tissue grafts is proposed. Specifically, this technique offers great convenience to prepare hollow hydrogel fibers with excellent mechanical properties and satisfactory biocompatibility. The tubular diameter can be readily adjusted within 6 mm, which renders the possibility of these hydrogel tubes to serve as small-diameter vascular grafts. In the model of animal trials, the hydrogel grafts with the capability of enduring arterial pressure are mechanically stable in rabbit carotid artery replacement. Because of its intrinsic simplicity and generality, the IDP technique is considered to be one of the reliable choices for more complicated bioengineering.
尽管生物打印材料和技术取得了巨大进展，但在打印具有令人满意的机械和化学性质的管状组织或器官（如血管、结肠和气管）时，仍然存在巨大挑战。在此，提出了一种基于界面扩散打印（IDP）技术的有前景的挤出系统，用于一步打印管状组织移植物。具体而言，该技术为制备具有优异机械性能和令人满意的生物相容性的中空水凝胶纤维提供了极大便利。管状直径可在6毫米内轻松调节，这使得这些水凝胶管有可能用作小直径血管移植物。在动物试验模型中，具有承受动脉压力能力的水凝胶移植物在兔颈动脉置换中机械稳定。由于其内在的简单性和通用性，IDP技术被认为是更复杂生物工程的可靠选择之一。
