Guo Junling, Suma Tomoya, Richardson Joseph J, Ejima Hirotaka
Department of Biomass Chemistry and Engineering, Sichuan University, Chengdu 610065, China.
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02115, United States.
ACS Biomater Sci Eng. 2019 Nov 11;5(11):5578-5596. doi: 10.1021/acsbiomaterials.8b01507. Epub 2019 Apr 30.
Polyphenols are building blocks with many advantages for engineering biomaterials because they are abundant in nature, biocompatible, biodegradable, and capable of assembly through different mechanisms. A variety of biomaterials across different length scales can be made with different physical/chemical properties and unique stimuli responses using modular and straightforward synthesis routes. We review the recent progress of biomaterials engineering based on polyphenols under three broad categories, namely, particles, films, and gels. The size and scale of the biomaterial along with the specific building blocks allow for a variety of biological applications including drug delivery and theranostics. The dynamic interactions, assembly processes, biological functions, and applications of a wide variety of representative polyphenol biomaterials are overviewed.
多酚是用于构建生物材料的基础成分，具有诸多优势，因为它们在自然界中含量丰富、具有生物相容性、可生物降解，并且能够通过不同机制进行组装。利用模块化且直接的合成路线，可以制备出具有不同物理/化学性质和独特刺激响应的、跨越不同长度尺度的各种生物材料。我们在粒子、薄膜和凝胶这三大类下综述了基于多酚的生物材料工程的最新进展。生物材料的尺寸和规模以及特定的基础成分使得其具有包括药物递送和治疗诊断学在内的多种生物学应用。本文概述了各种代表性多酚生物材料的动态相互作用、组装过程、生物学功能及应用。
