Mercadal Pablo A, Montesinos Maria Del Mar, Macchione Micaela A, Dalosto Sergio D, Bierbrauer Karina L, Calderón Marcelo, González Agustín, Picchio Matias L
Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5000 Córdoba, Argentina.
Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada (IPQA-CONICET), 5000 Córdoba, Argentina.
ACS Mater Lett. 2024 Jul 17;6(8):3726-3735. doi: 10.1021/acsmaterialslett.4c01212. eCollection 2024 Aug 5.
Natural polyphenols like tannic acid (TA) have recently emerged as multifunctional building blocks for designing advanced materials. Herein, we show the benefits of having TA in a dynamic liquid state using low-transition-temperature mixtures (LTTMs) for developing freezing-tolerant glues. TA was combined with betaine or choline chloride to create LTTMs, which direct the self-assembly of guanosine into supramolecular viscoelastic materials with high adhesion. Molecular dynamics simulations showed that the structural properties of the material are linked to strong hydrogen bonding in TA-betaine and TA-choline chloride mixtures. Notably, long-term and repeatable adhesion was achieved even at -196 °C due to the binding ability of TA's catechol and gallol units and the mixtures' glass transition temperature. Additionally, the adhesives demonstrated injectability and low toxicity against fibroblasts . These traits reveal the potential of these systems as bioadhesives for tissue repair, opening new avenues for creating multifunctional soft materials with bioactive properties.
像单宁酸（TA）这样的天然多酚最近已成为设计先进材料的多功能构建模块。在此，我们展示了在动态液态下使用低转变温度混合物（LTTMs）来开发耐冻胶水时TA的益处。TA与甜菜碱或氯化胆碱结合以创建LTTMs，其引导鸟苷自组装成具有高粘附力的超分子粘弹性材料。分子动力学模拟表明，该材料的结构特性与TA-甜菜碱和TA-氯化胆碱混合物中的强氢键有关。值得注意的是，由于TA的儿茶酚和没食子醇单元的结合能力以及混合物的玻璃化转变温度，即使在-196°C时也能实现长期且可重复的粘附。此外，这些粘合剂表现出可注射性且对成纤维细胞毒性低。这些特性揭示了这些系统作为组织修复生物粘合剂的潜力，为创建具有生物活性的多功能软材料开辟了新途径。
