Wang Haoyu, Jiang Limei, Wu Huanhuan, Zheng Weiya, Kan Di, Cheng Ran, Yan Juanjuan, Yu Chunshui, Sun Shao-Kai
Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin 300052, China.
Department of Radiology, Tianjin First Central Hospital, No. 24, Kangfu Road, Nankai District, Tianjin 300192, China.
ACS Biomater Sci Eng. 2019 Jul 8;5(7):3654-3662. doi: 10.1021/acsbiomaterials.9b00280. Epub 2019 Jun 7.
Photothermal therapy (PTT) with the advantages of high efficiency and minimal invasiveness is a promising technique for tumor therapy, but clinical application of PTT agents has been stifled by the great safety concerns. Herein, a deep blue iodine-starch-alginate (ALG) hydrogel is elegantly fabricated based on the classic and simple "iodine-starch test" for in vivo tumor PTT in a facile and mild way. The iodine-starch-ALG hydrogel composed of clinically used agents is fabricated by dispersing blue iodine-starch complex into alginate-Ca hydrogel, which guarantees the good chemical stability of iodine-starch complex via separating them from surrounding reductive environment. The iodine-starch-ALG hydrogel possesses favorable biocompatibility derived from the biosafe and degradable components and possesses good photothermal heating ability based on iodine-starch chromophore. The proposed iodine-starch-ALG hydrogel is successfully applied in tumor PTT in vitro and in vivo for the first time. This work lays down a novel way for the development of high-performance and biocompatible biomaterials via teaching old drugs new tricks.
光热疗法（PTT）具有高效和微创的优点，是一种很有前景的肿瘤治疗技术，但PTT试剂的临床应用因巨大的安全问题而受到阻碍。在此，基于经典且简单的“碘-淀粉测试”，以简便温和的方式巧妙制备了一种深蓝色碘-淀粉-海藻酸盐（ALG）水凝胶，用于体内肿瘤光热疗法。由临床使用的试剂组成的碘-淀粉-ALG水凝胶是通过将蓝色碘-淀粉复合物分散到海藻酸钙水凝胶中制备的，这通过将碘-淀粉复合物与周围的还原环境分离来保证其良好的化学稳定性。碘-淀粉-ALG水凝胶具有源自生物安全且可降解成分的良好生物相容性，并基于碘-淀粉发色团具有良好的光热加热能力。所提出的碘-淀粉-ALG水凝胶首次成功应用于体外和体内肿瘤光热疗法。这项工作通过让旧药有新用途，为开发高性能和生物相容性生物材料开辟了一条新途径。
