Li Lin, Wang Changping, Huang Quan, Xiao Jianru, Zhang Qiang, Cheng Yiyun
Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, P. R. China.
J Mater Chem B. 2018 Apr 28;6(16):2474-2480. doi: 10.1039/c8tb00091c. Epub 2018 Apr 12.
Hydrogels can be used to prolong the retention of photothermal agents in tumors to conduct repeated photothermal therapy (PTT) and thus reduce high-dose-induced toxicity, but the long-term retention of photothermal nanoparticles post-therapy still increases the risk of toxicity. In this work, we developed an injectable and degradable photothermal hydrogel to conduct repeated PTT. The hydrogel was composed of dendrimer-encapsulated platinum nanoparticles (DEPts) crosslinked aldehyde-modified dextran via imine bond formation. The hydrogel represented excellent photothermal effect and good biocompatibility. It was able to remain in tumors for a period of days to allow repeated PTT, leading to complete tumor regression. After treatment, the hydrogel was gradually degraded due to the decomposition of imine bonds. The study developed a practical photothermal hydrogel that allowed repeated PTT and reduced long-term retention-induced toxicity.
水凝胶可用于延长光热剂在肿瘤中的保留时间，以进行重复光热疗法（PTT），从而降低高剂量诱导的毒性，但治疗后光热纳米颗粒的长期保留仍会增加毒性风险。在这项工作中，我们开发了一种可注射且可降解的光热水凝胶来进行重复PTT。该水凝胶由树枝状聚合物包裹的铂纳米颗粒（DEPts）通过亚胺键形成交联醛修饰的葡聚糖组成。该水凝胶表现出优异的光热效应和良好的生物相容性。它能够在肿瘤中停留数天，以允许重复PTT，从而导致肿瘤完全消退。治疗后，由于亚胺键的分解，水凝胶逐渐降解。该研究开发了一种实用的光热水凝胶，可实现重复PTT并降低长期保留诱导的毒性。
