负载亚甲蓝的铜-胰蛋白胨复合纳米颗粒：一种新型的谷胱甘肽还原增强光动力治疗纳米平台。
Methylene Blue Loaded Cu-Tryptone Complex Nanoparticles: A New Glutathione-Reduced Enhanced Photodynamic Therapy Nanoplatform.
作者信息
Ruan Yudi, Jia Xiaodan, Wang Chao, Zhen Wenyao, Jiang Xiue
机构信息
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, No. 5625, Renmin Street, Changchun 130022, Jilin, China.
University of the Chinese Academy of Sciences, No. 19, Yuquan Road, Beijing 100049, China.
出版信息
ACS Biomater Sci Eng. 2019 Feb 11;5(2):1016-1022. doi: 10.1021/acsbiomaterials.8b01398. Epub 2019 Feb 1.
The concentration of intracellular reactive oxygen species directly determines the effect of photodynamic therapy. Reducing intracellular glutathione (GSH) content can increase reactive oxygen species (ROS) level. Therefore, it is extremely important to construct a nanoplatform that can promote photodynamic therapy by consuming GSH. In this study, we synthesized Cu-typtone complex nanoparticles (Cu-Try NPs) by a simple green method and demonstrated their ability to consume GSH to increase intracellular ROS for the first time. Photosensitizer methylene blue was loaded onto Cu-Try NPs (Cu-Try/MB NPs) for enhanced photodynamic therapy. Studies in vitro and in vivo illustrated that enhanced photodynamic therapy based on Cu-Try/MB NPs can kill cancer cells effectively.
细胞内活性氧物质的浓度直接决定光动力疗法的效果。降低细胞内谷胱甘肽（GSH）含量可提高活性氧（ROS）水平。因此，构建一种能够通过消耗GSH来促进光动力疗法的纳米平台极其重要。在本研究中，我们通过一种简单的绿色方法合成了铜-胰蛋白胨复合纳米颗粒（Cu-Try NPs），并首次证明了它们消耗GSH以增加细胞内ROS的能力。将光敏剂亚甲蓝负载到Cu-Try NPs上（Cu-Try/MB NPs）以增强光动力疗法。体外和体内研究表明，基于Cu-Try/MB NPs的增强光动力疗法能够有效杀死癌细胞。
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