Daqing Campus, Harbin Medical University, 39 Xinyang Rd., Daqing 163319, China.
Molecules. 2021 Sep 13;26(18):5567. doi: 10.3390/molecules26185567.
Glutathione (GSH) is involved in and regulates important physiological functions of the body as an essential antioxidant. GSH plays an important role in anti-oxidation, detoxification, anti-aging, enhancing immunity and anti-tumor activity. Herein, based on the physiological properties of GSH in different diseases, mainly including the strong reducibility of GSH, high GSH content in tumor cells, and the NADPH depletion when GSSH is reduced to GSH, we extensively report the design principles, effect, and potential problems of various nano-drugs in diabetes, cancer, nervous system diseases, fluorescent probes, imaging, and food. These studies make full use of the physiological and pathological value of GSH and develop excellent design methods of nano-drugs related to GSH, which shows important scientific significance and prominent application value for the related diseases research that GSH participates in or responds to.
谷胱甘肽（GSH）作为一种必需的抗氧化剂，参与并调节着人体的重要生理功能。GSH 在抗氧化、解毒、抗衰老、增强免疫力和抗肿瘤活性方面发挥着重要作用。在此，基于 GSH 在不同疾病中的生理特性，主要包括 GSH 的强还原性、肿瘤细胞中高 GSH 含量以及 GSSH 还原为 GSH 时 NADPH 的耗竭，我们广泛报道了各种纳米药物在糖尿病、癌症、神经系统疾病、荧光探针、成像和食品中的设计原则、效果和潜在问题。这些研究充分利用了 GSH 的生理和病理价值，开发了与 GSH 相关的优秀纳米药物设计方法，对于 GSH 参与或响应的相关疾病研究具有重要的科学意义和突出的应用价值。
