前列腺素E1单独以及对大鼠灌注下颌下腺主导管中交感神经介导的钠、钾转运的影响。

Effects of PGE1 alone and on sympathetically mediated Na, K transport in the perfused main submandibular duct of rat.

作者信息

Jirakulsomchok D, Schneyer C A

机构信息

Department of Physiology and Biophysics, University of Alabama, Birmingham 35294.

出版信息

Proc Soc Exp Biol Med. 1988 Jan;187(1):107-9. doi: 10.3181/00379727-187-42644.

DOI:10.3181/00379727-187-42644

PMID:3340611

Abstract

PGE1 was administered in 5 micrograms/kg doses every 5 min over a period of 70 min and Na and K transport in the perfused main duct of rat submandibular gland was examined during a period without stimulation of the sympathetic nerve as well as during stimulation of the sympathetic nerve. A 25% decrease in the amount of Na absorbed and a 42% decrease in the amount of K secreted occurred when PGE1 alone was administered; the same change occurred when the sympathetic nerve was stimulated in the presence of PGE1. These data show, for the first time, an effect of PGE1 alone on electrolyte transport, and suggest that specific PGE1 receptors are activated.

摘要

以5微克/千克的剂量每隔5分钟给予PGE1，持续70分钟，然后在未刺激交感神经以及刺激交感神经的期间，检测大鼠下颌下腺灌注主导管中的钠和钾转运情况。单独给予PGE1时，钠吸收量减少25%，钾分泌量减少42%；在PGE1存在的情况下刺激交感神经时，也出现同样的变化。这些数据首次表明了PGE1单独对电解质转运的影响，并提示特定的PGE1受体被激活。