Yu J H, Schneyer C A
Proc Soc Exp Biol Med. 1983 Jul;173(3):386-9. doi: 10.3181/00379727-173-41661.
The comparative effects of electrical stimulation of parasympathetic (chorda tympani nerve) and sympathetic innervation to the rat submandibular gland on calcium secretion were examined. The separate roles of alpha- and beta-adrenergic receptors in the regulation of calcium secretion during sympathetic nerve stimulation were also determined. The present study shows that the parasympathetic and sympathetic innervations to rat submandibular gland have very different effects on [Ca] of saliva; the regulatory influence of the sympathetic is more prominent than that of the parasympathetic innervation; [Ca] of submandibular saliva evoked by chorda stimulation was about 25 times less than that of saliva evoked by sympathetic stimulation. However, since total volume of chorda-evoked submandibular saliva was about 20 times greater than that of sympathetically evoked saliva, the total output of calcium following stimulation of either autonomic branch was similar. Glandular depletion of calcium for both kinds of nerve stimulation was also similar. Comparison with previous studies on the rat parotid gland shows that the role of the parasympathetic innervation in regulation of [Ca] of saliva and glandular depletion of calcium differed in the two glands while that of the sympathetic innervation was generally similar for both submandibular and parotid glands. Calcium secretion from rat submandibular gland was decreased during sympathetic nerve stimulation in the presence of propranolol, a beta-adrenergic blocker, while it was greatly increased when the sympathetic nerve was stimulated in the presence of phentolamine, an alpha-adrenergic blocker. Thus, it was concluded that with both glands beta-adrenoceptors play the major role in the regulation of calcium secretion.
研究了电刺激大鼠下颌下腺的副交感神经（鼓索神经）和交感神经对钙分泌的比较效应。还确定了α-和β-肾上腺素能受体在交感神经刺激期间钙分泌调节中的各自作用。本研究表明，大鼠下颌下腺的副交感神经和交感神经支配对唾液中的[Ca]有非常不同的影响；交感神经的调节作用比副交感神经支配更显著；鼓索刺激诱发的下颌下唾液中的[Ca]比交感神经刺激诱发的唾液中的[Ca]少约25倍。然而，由于鼓索诱发的下颌下唾液总量比交感神经诱发的唾液总量大约20倍，因此刺激任一自主神经分支后钙的总输出量相似。两种神经刺激引起的腺体钙消耗也相似。与先前对大鼠腮腺的研究比较表明，副交感神经支配在唾液[Ca]调节和腺体钙消耗中的作用在两个腺体中有所不同，而交感神经支配在颌下腺和腮腺中通常相似。在β-肾上腺素能阻滞剂普萘洛尔存在的情况下，交感神经刺激期间大鼠下颌下腺的钙分泌减少，而在α-肾上腺素能阻滞剂酚妥拉明存在的情况下刺激交感神经时，钙分泌大大增加。因此，得出的结论是，在两个腺体中，β-肾上腺素能受体在钙分泌调节中起主要作用。
