Martigne M, Domingo N, Chanussot F, Nalbone G, Lafont H, Hauton J
INSERM U-130, Marseille, France.
Proc Soc Exp Biol Med. 1988 Feb;187(2):229-34. doi: 10.3181/00379727-187-42659.
[14C]Cholesterol associated with liposomes with or without anionic polypeptidic fraction was administered intravenously to the rat. The cholesterol originated from liposomes including anionic polypeptidic fraction is secreted in bile much later, is stored in liver in higher quantity, and is metabolized into bile salts in lesser quantity during the 4 hr of experimentation than the cholesterol issued from liposomes exempt of anionic polypeptidic fraction. From these results it can be postulated that the cholesterol associated with liposomes containing anionic polypeptidic fraction might be directed in a particular liver pathway.
将含有或不含有阴离子多肽部分的脂质体相关的[14C]胆固醇静脉注射给大鼠。与含有阴离子多肽部分的脂质体相关的胆固醇在胆汁中的分泌要晚得多，在实验的4小时内，其在肝脏中的储存量更高，而代谢为胆汁盐的量则比不含阴离子多肽部分的脂质体中的胆固醇少。从这些结果可以推测，与含有阴离子多肽部分的脂质体相关的胆固醇可能被导向特定的肝脏途径。
