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Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques.

作者信息

Tang Jing-Jie, Li Jia-Gui, Qi Wei, Qiu Wen-Wei, Li Pei-Shan, Li Bo-Liang, Song Bao-Liang

出版信息

Cell Metab. 2021 Jan 5;33(1):222. doi: 10.1016/j.cmet.2020.11.013.

DOI:10.1016/j.cmet.2020.11.013
PMID:33406401
Abstract
摘要

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Docosahexaenoic acid inhibits proteolytic processing of sterol regulatory element-binding protein-1c (SREBP-1c) via activation of AMP-activated kinase.二十二碳六烯酸通过激活AMP活化蛋白激酶抑制固醇调节元件结合蛋白-1c（SREBP-1c）的蛋白水解加工。
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