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Chemotherapy-Induced Ca Release Stimulates Breast Cancer Stem Cell Enrichment.

作者信息

Lu Haiquan, Chen Ivan, Shimoda Larissa A, Park Youngrok, Zhang Chuanzhao, Tran Linh, Zhang Huimin, Semenza Gregg L

出版信息

Cell Rep. 2021 Jan 5;34(1):108605. doi: 10.1016/j.celrep.2020.108605.

DOI:10.1016/j.celrep.2020.108605
PMID:33406433
Abstract
摘要

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Chemotherapy-Induced Ca Release Stimulates Breast Cancer Stem Cell Enrichment.化疗诱导的钙释放刺激乳腺癌干细胞富集。
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Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype.化疗引发依赖缺氧诱导因子-1的谷胱甘肽合成及铜螯合，进而诱导乳腺癌干细胞表型。
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Hyaluronic acid hydrogels with defined crosslink density for the efficient enrichment of breast cancer stem cells.具有明确交联密度的透明质酸水凝胶可有效富集乳腺癌干细胞。
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Combination therapy targeting both cancer stem-like cells and bulk tumor cells for improved efficacy of breast cancer treatment.针对癌症干细胞样细胞和实体瘤细胞的联合疗法以提高乳腺癌治疗效果。
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