State Key Laboratory of Bioactive Molecules and Druggability Assessment; MOE Key Laboratory of Tumor Molecular Biology; Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, 510632, China.
Functional Experimental Teaching Center, School of Medicine, Jinan University, Guangzhou, 510632, China.
Acta Pharmacol Sin. 2023 Sep;44(9):1725-1736. doi: 10.1038/s41401-023-01093-8. Epub 2023 May 11.
Chemotherapy, the most widely accepted treatment for malignant tumors, is dependent on cell death induced by various drugs including antimetabolites, alkylating agents, mitotic spindle inhibitors, antitumor antibiotics, and hormonal anticancer drugs. In addition to causing side effects due to non-selective cytotoxicity, chemotherapeutic drugs can initiate and promote metastasis, which greatly reduces their clinical efficacy. The knowledge of how they induce metastasis is essential for developing strategies that improve the outcomes of chemotherapy. Herein, we summarize the recent findings on chemotherapy-induced metastasis and discuss the underlying mechanisms including tumor-initiating cell expansion, the epithelial-mesenchymal transition, extracellular vesicle involvement, and tumor microenvironment alterations. In addition, the use of combination treatments to overcome chemotherapy-induced metastasis is also elaborated.
化疗是恶性肿瘤最广泛接受的治疗方法，它依赖于各种药物诱导的细胞死亡，包括抗代谢物、烷化剂、有丝分裂纺锤体抑制剂、抗肿瘤抗生素和激素抗癌药物。除了由于非选择性细胞毒性引起的副作用外，化疗药物还可以引发和促进转移，这大大降低了它们的临床疗效。了解它们如何诱导转移对于制定改善化疗效果的策略至关重要。本文总结了化疗诱导转移的最新研究进展，并讨论了相关的潜在机制，包括肿瘤起始细胞的扩增、上皮-间充质转化、细胞外囊泡的参与以及肿瘤微环境的改变。此外，还阐述了联合治疗以克服化疗诱导转移的应用。
