Clinical Laboratory Center, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang, China.
Aging (Albany NY). 2021 Jan 6;13(1):1410-1421. doi: 10.18632/aging.202357.
In this study, we evaluated the association of modified Glasgow Prognostic Score (mGPS) with prognosis in pancreatic cancer (PC) by performing a meta-analysis. Potentially eligible studies were shortlisted by searching PubMed, Embase, Web of Science, Scopus, and the Cochrane Library. A total of 4,629 patients with PC from 25 studies were finally included in this meta-analysis. Meta-analyses were performed using a random-effects model or fixed-effect model according to heterogeneity. We pooled the hazard ratios (HRs) with 95% confidence intervals (CIs) to estimate the association between mGPS and overall survival (OS). The results showed that elevated mGPS correlated with poor OS in patients with PC (HR=1.92, 95% CI=1.60-2.30, p<0.002). In addition, subgroup analysis indicated that increased mGPS remained a significant prognostic factor irrespective of the study design, region, disease status, treatment, survival analysis, cancer type, study center, or the Newcastle-Ottawa Scale (NOS) score (all p<0.05). There was a significant correlation between higher mGPS and male gender (Odds ratio [OR]=1.30, 95% CI=1.01-1.67, p=0.038). Elevated pretreatment mGPS is a marker of poor prognosis in patients with PC. As an easily available and cost-effective inflammatory parameter, mGPS can serve as a promising tool for prognostication in PC.
在这项研究中，我们通过荟萃分析评估了改良格拉斯哥预后评分（mGPS）与胰腺癌（PC）预后的相关性。通过搜索 PubMed、Embase、Web of Science、Scopus 和 Cochrane Library，对潜在符合条件的研究进行了筛选。最终共有 25 项研究的 4629 名 PC 患者纳入本荟萃分析。根据异质性，使用随机效应模型或固定效应模型进行荟萃分析。我们使用合并危险比（HR）和 95%置信区间（CI）来估计 mGPS 与总生存期（OS）之间的相关性。结果表明，mGPS 升高与 PC 患者的 OS 不良相关（HR=1.92，95%CI=1.60-2.30，p<0.002）。此外，亚组分析表明，升高的 mGPS 仍然是一个显著的预后因素，无论研究设计、地区、疾病状态、治疗、生存分析、癌症类型、研究中心或纽卡斯尔-渥太华量表（NOS）评分（均 p<0.05）。较高的 mGPS 与男性性别之间存在显著相关性（优势比[OR]=1.30，95%CI=1.01-1.67，p=0.038）。治疗前 mGPS 升高是 PC 患者预后不良的标志。作为一种易于获得且具有成本效益的炎症参数，mGPS 可以作为 PC 预后的一种有前途的工具。
